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Calpain inhibition by calpeptin modulates adipocyte lipid metabolism and secretome-mediated inflammatory crosstalk with hepatocytesNARA Subscribed
Objective Calpeptin, a calpain inhibitor with potential for treating inflammatory diseases, reduces extracellular vesicle (EV) secretion. While adipose tissue is a recognized target of calpeptin, its effects on lipid metabolism remain unknown. We investigated calpeptin’s impact on fatty acid (FA) profiles and metabolic pathways in human Simpson-Golabi-Behmel Syndrome adipocytes and their EVs. Methods Adipocytes were treated wi...
SNAPSHOT USA 2024: Year 6 of the Coordinated National Camera Trap Survey of the United StatesNARA Subscribed
Motivation SNAPSHOT USA is an annual, multi‐contributor camera trap survey of mammals across the United States. The growing SNAPSHOT USA dataset is intended for tracking the spatial and temporal responses of mammal populations to changes in land use, land cover and climate. These data will be useful for exploring the drivers of spatial and temporal changes in relative abundance and distribution, as well as the impacts of speci...
Saving what’s left: conservation genomics of Plethobasus, a critically endangered genus of freshwater musselNARA Subscribed
Freshwater mussels (Order Unionida) are diverse, yet highly imperiled, bivalves. In the United States, about 10% of approximately 300 native species are extinct and around 60% of the remaining species are imperiled. Conservation practitioners are engaged in recovery efforts, but without genetic oversight these activities can be counterproductive. The freshwater mussel genus Plethobasus consists of three federally endangered sp...
Towards developing an integrated approach for the treatment of white root rot in commercial avocado orchardsNARA Subscribed
In 2016, Dematophora necatrix , the causal agent of white root rot (WRR), was identified in an avocado orchard in South Africa. Since then, this pathogen has spread to all avocado-growing regions in the country. This study aimed to evaluate the in-field efficacy of the biological control product EXTRASOL ( Bacillus subtilis and Bacillus amyloquefaciens subsp. plantarum ) and the fungicide fluazinam against WRR in two commercia...