P. Boon results 36
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Prolonging survival in good health is a fundamental societal goal. However, the leading determinants of disability-free survival in healthy older people have not been well established. Data from ASPREE, a bi-national placebo-controlled trial of aspirin with 4.7 years median follow-up, was analysed. At enrolment, participants were healthy and without prior cardiovascular events, dementia or persistent physical disability. Disab...
Sialic Acid-Engineered IL4–10 Fusion Protein is Bioactive and Rapidly Cleared from the CirculationNARA Subscribed
Purpose Modulating sialylation of therapeutic glycoproteins may be used to influence their clearance and systemic exposure. We studied the effect of low and high sialylated IL4–10 fusion protein (IL4–10 FP) on in vitro and in vivo bioactivity and evaluated the effect of differential sialylation on pharmacokinetic parameters. Methods CHO cell lines producing low (IL4–10 FP lowSA) and high sialylated (IL4–10 FP highSA) fusion pr...
Marine stepping‐stones: Connectivity of Mytilus edulis populations between offshore energy installationsNARA Subscribed
Recent papers have suggested that epifaunal organisms use artificial structures as stepping‐stones to spread to areas that are too distant to reach in a single generation. With thousands of artificial structures present in the North Sea, we test the hypothesis that these structures are connected by water currents and act as an interconnected reef. Population genetic structure of the blue mussel, Mytilus edulis , was expected t...
Abundance and generalisation in mutualistic networks: solving the chicken‐and‐egg dilemmaNARA Subscribed
A frequent observation in plant–animal mutualistic networks is that abundant species tend to be more generalised, interacting with a broader range of interaction partners than rare species. Uncovering the causal relationship between abundance and generalisation has been hindered by a chicken‐and‐egg dilemma: is generalisation a by‐product of being abundant, or does high abundance result from generalisation? Here, we analyse a...
Bacterial host interaction of GFP‐labelled Vibrio anguillarum HI‐610 with gnotobiotic sea bass, Dicentrarchus labrax (L.), larvaeNARA Subscribed
The location and cell damage caused by Vibrio anguillarum , the causative agent of classical vibriosis, within the developing gut of the newly hatched sea bass, Dicentrarchus labrax (L.), is unknown. A gnotobiotic sea bass model was used to investigate the early interactions of V. anguillarum with sea bass larvae. In the present study, germ‐free sea bass larvae were orally exposed to a V. anguillarum HI‐610 pathogen labelled w...
Development of a bacterial challenge test for gnotobiotic sea bass ( Dicentrarchus labrax ) larvaeNARA Subscribed
Summary The use of probiotic microorganisms in aquaculture is gaining a lot of interest. Gnotobiotic model systems are required in order to fully understand the effects and modes‐of‐action of these microorganisms, as the native microbial communities present in non‐sterile animals can lead to false conclusions. In this study, a gnotobiotic sea bass larvae ( Dicentrarchus labrax ) test system was developed. In order to obtain ba...
The life history of Tenualosa macrura in Sarawak, further notes on protandry in the genus and management strategiesNARA Subscribed
The contraction of Tenualosa macrura (Bleeker) to the Sarawak coast and a small part of Sumatra, and the decline in its fishery mirror what has happened to three other species in the genus. Little was known of this species in its last stronghold in Sarawak where it is important for management and conservation reasons to understand its biology and life history. It forms part of a multispecies fishery where effort is uniform, bu...
Neuropsychological investigation into the carcinoid syndromeNARA Subscribed