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Parasites play a critical yet understudied role in Arctic ecosystems, particularly within key subsistence species such as Arctic char ( Salvelinus alpinus ). As the Arctic undergoes rapid climate-driven change, establishing baseline parasite biodiversity is essential for monitoring ecological shifts and anticipating emerging health and conservation concerns. This study provides the most comprehensive assessment to date of Arct...
CLC F , Not CrcB , Protects Pseudomonas putida ATCC 12633 During Intense Fluoride StressNARA Subscribed
Fluoride is abundant in the Earth's crust but is rarely used by biological systems and is toxic inside cells. Most prokaryotic genomes contain genes encoding fluoride export channels, known as CrcB, or fluoride/proton antiporters, known as CLC F . Prokaryotes rely on one type only. In this study, Pseudomonas putida ATCC 12633 that natively expressed a chromosomally‐encoded CrcB was engineered with plasmids containing a CLC F e...
Interpretable deep learning reveals spatiotemporal MRI features of brain aging that align with neurodegenerationNARA Subscribed
Cortical thinning and atrophy are hallmarks of brain aging that have been characterized using magnetic resonance imaging (MRI). Brain aging involves many neuroanatomic features whose effects on brain structure remain unexplored. To address this challenge, we trained interpretable deep neural networks (DNNs) to estimate brain age (BA) from T 1 -weighted ( T 1 w) MRI. By identifying MRI features unapparent to humans, DNNs can fi...
Stability Specifications for Climate Data Records: Their Meaning and Application in Evaluating Geophysical Trend UncertaintyNARA Subscribed
When quantifying changes over time in the natural environment, the stability of the observations used should be considered. Stability conceptually refers to how accurately true geophysical changes and trends are reflected in observational data. We argue the need for a better approach to defining and quantifying stability consistently across climate data records. We propose that the appropriate stability metric is the stability...
Alzheimer’s disease (AD) disproportionately affects women and carriers of the apolipoprotein E ε4 allele (APOE4), yet little is known about how sex and APOE interact to influence white matter (WM) integrity during disease progression. We integrated diffusion MRI and matched blood transcriptomic data to investigate these interactions and their underlying biological mechanisms. WM microstructure was quantified using diffusion te...
A phase I clinical study to evaluate rapid, high-volume, subcutaneous auto-injector tolerability with recombinant human hyaluronidaseNARA Subscribed
Until recently, approved handheld auto-injectors (AIs) have been limited to volumes ≤ 2 mL. A prototype rapid high-volume AI (HVAI) that can deliver 10 mL in 30 s was developed to administer therapeutics co-formulated with a proprietary recombinant human hyaluronidase PH20 (rHuPH20). This phase I, open-label study assessed the tolerability of subcutaneous (SC) injections of 10% (100 mg/mL) immunoglobulin G (IgG) solution co-ad...
Extreme physical-oceanographic events, such as marine heatwaves, fluvial floods, droughts and storm surges, have major impacts on local communities, economic sectors and ecosystems, and their frequency, intensity and duration increase due to climate change. There is a lack of understanding of the systemic drivers of extreme events as well as of their interconnected impacts on estuarine and coastal ecosystems. This knowledge is...