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Recent mycological surveys in Northern Mindanao, Philippines, have uncovered two morphologically distinct, previously undescribed species of Ophiocordyceps ( Hypocreales : Ophiocordycipitaceae ). Using an integrative framework that combines morphological assessment with multilocus phylogenetics (nrSSU, nrLSU, tef1‐α , rpb1 , rpb2 ), we propose Ophiocordyceps rogongonensis sp. nov. and Ophiocordyceps xylostellae sp. nov. Phylog...
Metabolic Profiles of Encapsulated Chondrocytes Exposed to Short-Term Simulated MicrogravityNARA Subscribed
The mechanism by which chondrocytes respond to reduced mechanical loading environments and the subsequent risk of developing osteoarthritis remains unclear. This is of particular concern for astronauts. In space the reduced joint loading forces during prolonged microgravity (10 −6 g) exposure could lead to osteoarthritis (OA), compromising quality of life post-spaceflight. In this study, we encapsulated human chondrocytes in a...
Nonequilibrium spherulitic magnetite in the Ryugu samplesNARA Subscribed
Multiple sclerosis (MS) is a progressive disease that often affects the cerebellum. It is characterised by demyelination, inflammation, and neurodegeneration within the central nervous system. Damage to the cerebellum in MS is associated with increased disability and decreased quality of life. Symptoms include gait and balance problems, motor speech disorder, upper limb dysfunction, and oculomotor difficulties. Monitoring symp...
Prolonging survival in good health is a fundamental societal goal. However, the leading determinants of disability-free survival in healthy older people have not been well established. Data from ASPREE, a bi-national placebo-controlled trial of aspirin with 4.7 years median follow-up, was analysed. At enrolment, participants were healthy and without prior cardiovascular events, dementia or persistent physical disability. Disab...
Quantifying risks avoided by limiting global warming to 1.5 or 2 °C above pre-industrial levelsNARA Subscribed
The Paris Agreement aims to constrain global warming to ‘well below 2 °C’ and to ‘pursue efforts’ to limit it to 1.5 °C above pre-industrial levels. We quantify global and regional risk-related metrics associated with these levels of warming that capture climate change–related changes in exposure to water scarcity and heat stress, vector-borne disease, coastal and fluvial flooding and projected impacts on agriculture and the e...
Common, low-frequency, rare, and ultra-rare coding variants contribute to COVID-19 severityNARA Subscribed
The combined impact of common and rare exonic variants in COVID-19 host genetics is currently insufficiently understood. Here, common and rare variants from whole-exome sequencing data of about 4000 SARS-CoV-2-positive individuals were used to define an interpretable machine-learning model for predicting COVID-19 severity. First, variants were converted into separate sets of Boolean features, depending on the absence or the pr...
Global and regional aggregate damages associated with global warming of 1.5 to 4 °C above pre-industrial levelsNARA Subscribed
We quantify global and regional aggregate damages from global warming of 1.5 to 4 ° C above pre-industrial levels using a well-established integrated assessment model, PAGE09. We find mean global aggregate damages in 2100 of 0.29% of GDP if global warming is limited to about 1.5 °C (90% confidence interval 0.09–0.60%) and 0.40% for 2 °C (range 0.12–0.91%). These are, respectively, 92% and 89% lower than mean losses of 3.67% of...
Interactions between sediment microbial ecology and physical dynamics drive heterogeneity in contextually similar depositional systemsNARA Subscribed
This study focuses on the interactions between sediment stability and biological and physical variables that influence the erodibility across different habitats. Sampling at short‐term temporal scales illustrated the persistence of the microphytobenthos (MPB) biomass even during periods of frequent, high physical disturbance. The role of MPB in biological stabilization along the changing sedimentary habitat was also assessed....
Harmony on the prairie? Grassland plant and animal community responses to variation in climate across land‐use gradientsNARA Subscribed
Human induced climate and land‐use change are severely impacting global biodiversity, but how community composition and richness of multiple taxonomic groups change in response to local drivers and whether these responses are synchronous remains unclear. We used long‐term community‐level data from an experimentally manipulated grassland to assess the relative influence of climate and land use as drivers of community structure...
The unexpected mating system of the androdioecious barnacle Chelonibia testudinaria (Linnaeus 1758)NARA Subscribed
Androdioecy was first described by Darwin in his seminal work on barnacle diversity; he identified males and hermaphrodites in the same reproductive population. Today, we realize that many androdioecious plants and animals share astonishing similarities, particularly with regard to their evolutionary history and mating system. Notably, these species were ancestrally dioecious, and their mating system has the following characte...