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Gene-environment interactions, leading to immune-brain cross-talk and neuroinflammation are increasingly recognised in neurodevelopmental disorders (NDDs), such as autistic regression and paediatric acute onset neuropsychiatric syndrome (PANS). Nonsteroidal anti-inflammatory drugs, including ibuprofen, provides relief to some neuropsychiatric symptoms, however, the therapeutic mechanisms are unclear. We describe the benefit of...
Extreme climatic events and gradual climate change are increasingly anticipated to interact and reshape ecological communities. However, the combined effects of ocean warming, acidification and marine heatwaves on host‐associated microbial communities and their potential role in host adaptation remain poorly understood. Here, we assessed shifts in gut microbiome communities and their associations with physiological performance...
Characterising the Radionuclide Fingerprint of an Advanced Gas-Cooled Nuclear Power ReactorNARA Subscribed
Radionuclides are monitored in the atmosphere for the signatures of nuclear explosions, as part of the verification of the Comprehensive Nuclear-Test-Ban Treaty (CTBT). Civil nuclear facilities, such as Nuclear Power Plants (NPPs) and Isotope Production Facilities (IPFs) are sources of anthropogenic radionuclides in the atmosphere and these signatures are sometimes indistinguishable to those of a nuclear explosion. In order to...
Environmental flows assessment integrating snow trout habitat requirements in the Shakhimardan basin, Central AsiaNARA Subscribed
The increasing demand for hydropower development in Central Asia threatens the ecological integrity of high-mountain rivers. This study applies an ecohydraulics-based approach to assess environmental flow requirements for a diversion hydropower project on the Koksu River, Uzbekistan. We integrated high-resolution 2D hydrodynamic modeling with novel habitat data for snow trout ( Schizothorax eurycephalus ), incorporating fuzzy...
Optimising parent selection in plant breeding: comparing metaheuristic algorithms for genotype buildingNARA Subscribed
Stacking desirable haplotypes across the genome to develop superior genotypes has been implemented in several crop species. A major challenge in Optimal Haplotype Selection is identifying a set of parents that collectively contain all desirable haplotypes, a complex combinatorial problem with countless possibilities. In this study, we evaluated the performance of metaheuristic search algorithms (MSAs)—genetic algorithm (GA), d...
Pulse oximeters’ (POs) varying performance based on skin tones has been highly publicised. Compared to arterial blood gas analysis, POs tend to overestimate oxygen saturation (SpO 2 ) values for people with darker skin (occult hypoxemia). The objective is to develop a test bench for assessing commercial home and hospital-based POs in controlled laboratory conditions. A laboratory simulator was used to mimic different SpO 2 val...
Aim The urgency for remote, reliable and scalable biodiversity monitoring amidst mounting human pressures on ecosystems has sparked worldwide interest in Passive Acoustic Monitoring (PAM), which can track life underwater and on land. However, we lack a unified methodology to report this sampling effort and a comprehensive overview of PAM coverage to gauge its potential as a global research and monitoring tool. To address this...
Academic review, promotion, and tenure processes place a premium on frequent publication in high‐impact factor (IF) journals. However, conservation often relies on species‐specific information that is unlikely to have the broad appeal needed for high‐IF journals. Instead, this information is often distributed in low‐IF, taxa‐ and region‐specific journals. This suggests a potential mismatch between the incentives for academic r...
Warming, ocean acidification, and deoxygenation are increasingly putting pressure on marine ecosystems. At the same time, thawing permafrost and decomposing hydrates in Arctic shelf seas may release large amounts of methane (CH4) into the water column, which could accelerate local ocean acidification and contribute to climate change. The key parameters to observing and understanding these complex processes and feedback mechani...
Heatwave predicts a shady future for insects: impacts of an extreme weather event on a chalk grassland in Bedfordshire, UKNARA Subscribed
Climate change is set to become one of the leading causes of biodiversity loss worldwide, with extreme weather events projected to increase in frequency. Ectothermic animals such as insects are at particular risk, especially when they are isolated and unable to move through the landscape to track suitable climate. To protect such taxa, it is important to understand how they are impacted by extreme weather events and whether ma...