P. Hirsch results 58
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Targeting west nile virus replication by xanthine inhibitorsNARA Subscribed
Assessing the linkage between breeding and non-breeding areas has important implications for understanding the fundamental biology of and conserving animal species. This is a challenging task for marine species, and in sea turtles a combination of stable isotope analysis (SIA) and satellite telemetry has been increasingly used. The Northwest Atlantic (NWA) loggerhead ( Caretta caretta ) Regional Management Unit, one of the lar...
Current recommendations for cancer surveillance in Gorlin syndrome: a report from the SIOPE host genome working group (SIOPE HGWG)NARA Subscribed
Gorlin syndrome (MIM 109,400), a cancer predisposition syndrome related to a constitutional pathogenic variation (PV) of a gene in the Sonic Hedgehog pathway ( PTCH1 or SUFU) , is associated with a broad spectrum of benign and malignant tumors. Basal cell carcinomas (BCC), odontogenic keratocysts and medulloblastomas are the main tumor types encountered, but meningiomas, ovarian or cardiac fibromas and sarcomas have also been...
The rhabdoid tumor (RT) predisposition syndromes 1 and 2 (RTPS1 and 2) are rare genetic conditions rendering young children vulnerable to an increased risk of RT, malignant neoplasms affecting the kidney, miscellaneous soft-part tissues, the liver and the central nervous system (Atypical Teratoid Rhabdoid Tumors, ATRT). Both, RTPS1&2 are due to pathogenic variants (PV) in genes encoding constituents of the BAF chromatin remode...
Genetic testing and surveillance in infantile myofibromatosis: a report from the SIOPE Host Genome Working GroupNARA Subscribed
Infantile myofibromatosis (IM), which is typically diagnosed in young children, comprises a wide clinical spectrum ranging from inconspicuous solitary soft tissue nodules to multiple disseminated tumors resulting in life-threatening complications. Familial IM follows an autosomal dominant mode of inheritance and is linked to PDGFRB germline variants. Somatic PDGFRB variants were also detected in solitary and multifocal IM lesi...
Personality‐dependent inter‐ and intraspecific foraging competition in the invasive round goby, Neogobius melanostomusNARA Subscribed
This study examines the impact of boldness on foraging competition of the highly invasive round goby Neogobius melanostomus Pallas 1815. Individual risk tolerance, or boldness, was measured as the time to resume movement after a simulated predation strike. Fish that resumed movement faster were categorized as “bold,” fish that took more time to resume movement were categorized as “shy” and those that fell in between these two...
Invasion syndromes: a systematic approach for predicting biological invasions and facilitating effective managementNARA Subscribed
Our ability to predict invasions has been hindered by the seemingly idiosyncratic context-dependency of individual invasions. However, we argue that robust and useful generalisations in invasion science can be made by considering “invasion syndromes” which we define as “a combination of pathways, alien species traits, and characteristics of the recipient ecosystem which collectively result in predictable dynamics and impacts,...
Invasive species represent a threat to aquatic ecosystems globally; however, impacts can be heterogenous across systems. Documented impacts of invasive zebra mussels ( Dreissena polymorpha ) and spiny water fleas ( Bythotrephes cederströmii ; hereafter Bythotrephes ) on native fishes are variable and context dependent across locations and time periods. Here, we use a hierarchical Bayesian analysis of a 35-year dataset on two f...
NEOTROPICAL XENARTHRANS: a data set of occurrence of xenarthran species in the NeotropicsNARA Subscribed
Xenarthrans—anteaters, sloths, and armadillos—have essential functions for ecosystem maintenance, such as insect control and nutrient cycling, playing key roles as ecosystem engineers. Because of habitat loss and fragmentation, hunting pressure, and conflicts with domestic dogs, these species have been threatened locally, regionally, or even across their full distribution ranges. The Neotropics harbor 21 species of armadillos,...
Mid‐Pleistocene thin‐skinned glaciotectonic thrusting of the Aberdeen Ground Formation, Central Graben region, central North SeaNARA Subscribed
This paper presents the results of a high‐resolution 2D seismic survey of mid‐Pleistocene glaciogenic sediments in the Central Graben region of the central North Sea. Sediments have undergone major glaciotectonic thrusting and folding associated with the repeated southerly advance of a mid‐Pleistocene ice sheet. The total observed length of the thrust‐stacked section is approximately 5–6 km, comprising a series of discrete thr...