High rates of mortality in non-small cell lung cancer lung cancer is due to inherent and acquired resistance to systemic therapies and subsequent metastatic burden. Metastasis is supported by suppression of the immune system at secondary organs and within the circulation. Modulation of the immune system is now being exploited as a therapeutic target with immune checkpoint inhibitors. The tracking of therapeutic efficacy in a r...

We propose a dilatant, two-layer debris flow model validated by full-scale density/saturation measurements obtained from the Swiss Illgraben test site. Like many existing models, we suppose the debris flow consists of a matrix of solid particles (rocks and boulders) that is surrounded by muddy fluid. However, we split the muddy fluid into two fractions. One part, the inter-granular fluid, is bonded to the solid matrix and fill...