P. Jack results 258
· Newest (Page 1/11, per page 25)
Author: P. Jack ×Clear All Filters
Search Results
Total plasma N-glycomic patterns of COVID-19 diseaseNARA Subscribed
Total plasma N -glycans alter in disease states, with few studies focused on COVID-19. A discovery cohort of 310 COVID-19 patients, replicated with 97 COVID-19 patients and tested with 100 COVID-19 patients, was used to unearth the N -glycans capable of distinguishing infection, as well as prognosis of intensive care unit (ICU) admission and mortality. All significant bisected glycans were decreased in patients compared to con...
Human and Porcine Marginal Chordal Forces in a Vacuum Based Physiological In Vitro Mitral Valve ModelNARA Subscribed
Introduction This study aimed to quantitatively investigate the role of marginal chordae of the mitral valve during static closure by analyzing the force within these chordae and its potential correlation with the transvalvular pressure. Materials and Methods Porcine (n = 10) and human (n = 4) mitral valves were mounted in a saddle-shaped annulus clamp, while an in vitro system was utilized to replicate a physiological systoli...
Cryptomelane (K-OMS-2) (K(Mn 4+ , Mn 2+ ) 8 O 16 ) is a manganese-oxide mineral that is abundant in soils and rock coatings globally and is gaining importance in materials science and industrial mineralogy. The crystal structure is composed of 2 × 2 octahedra that creates a tunnel space for K + . Low-weight percent (wt%) europium (Eu)-doped, high-wt% Eu-doped, low-wt% cerium (Ce)-doped, and high-wt% Ce-doped cryptomelane were...
The disjunct mesic forests of the Pacific Northwest, occurring on the west side of North America's Coastal Ranges as well as in the Northern Rocky Mountains, have emerged as a model system for comparative phylogeography. Less well‐known, however, are the alpine and subalpine plants that mirror this distribution—here referred to as the Maritime Alpine Disjuncts. The phylogeographic histories of lowland coastal disjunct species...
Non‐Invasive Measures of DNA Methylation Capture Molecular Aging in Wild Capuchin MonkeysNARA Subscribed
Elucidating the socio‐ecological factors that shape patterns of aging in long‐lived vertebrates is of broad interest to evolutionary biologists, geroscientists, and ecologists. However, research on aging in wild populations still faces challenges due to the difficulty of measuring cellular hallmarks of aging non‐invasively and the difficulty of accurately estimating age in long‐lived species. Here, we demonstrate that cellular...
A Novel Polyphosphate‐Degrading Enzyme Confers Growth on Exogenous Polyphosphate in the Archaeon Haloferax volcaniiNARA Subscribed
Polyphosphate (polyP) is an inorganic biopolymer of orthophosphate (Pi) that plays roles in many central biochemical processes in microorganisms, including acting as a cellular reservoir of phosphorus. The microbial metabolism of polyP is considered limited to its intracellular cycling by kinases and exopolyphosphatases. However, little is known about polyP metabolism in the Archaea. Notably, many haloarchaea, including Halofe...
Effect of six weeks ubiquinol supplementation on mitochondrial respiratory function and exercise capacity in healthy malesNARA Subscribed
Coenzyme Q10 (CoQ 10 ) is an integral component of the mitochondrial electron transfer system. Most studies have administered the oxidised form of CoQ 10 (ubiquinone) and observed no effects on mitochondrial respiratory function or endurance exercise performance. The reduced form of CoQ 10 , ubiquinol (UQH 2 ), has greater bioavailability than ubiquinone, but the effects of UQH 2 supplementation on mitochondrial respiratory fu...
Interpretable deep learning reveals spatiotemporal MRI features of brain aging that align with neurodegenerationNARA Subscribed
Cortical thinning and atrophy are hallmarks of brain aging that have been characterized using magnetic resonance imaging (MRI). Brain aging involves many neuroanatomic features whose effects on brain structure remain unexplored. To address this challenge, we trained interpretable deep neural networks (DNNs) to estimate brain age (BA) from T 1 -weighted ( T 1 w) MRI. By identifying MRI features unapparent to humans, DNNs can fi...
Ti solubility in biotite at low pressure in metapelitic systems: the Torres del Paine caseNARA Subscribed
The Torres del Paine Intrusive Complex (TPIC) is a shallowly emplaced pluton surrounded by a well-defined contact aureole, providing an ideal setting to test Ti-in-biotite thermometry. We compare existing Ti-in-biotite thermometers with phase petrology constraints and found that they systematically overestimate peak metamorphic temperatures. This discrepancy arises from a significant increase in Ti solubility at low pressures...
Alzheimer’s disease (AD) disproportionately affects women and carriers of the apolipoprotein E ε4 allele (APOE4), yet little is known about how sex and APOE interact to influence white matter (WM) integrity during disease progression. We integrated diffusion MRI and matched blood transcriptomic data to investigate these interactions and their underlying biological mechanisms. WM microstructure was quantified using diffusion te...
Wild and Naturalized Hatchery Brown Trout: A Comparison of Movement, Space Use, and Survival in a Large LakeNARA Subscribed
Most research comparing wild and hatchery‐produced fish focuses on recently stocked individuals. As a result, these studies only investigate the behavior of naive hatchery fish, leaving a knowledge gap regarding long‐term survivors. We compared the movement, space use, and survival of wild and hatchery‐reared brown trout ( Salmo trutta ) that had survived for multiple years in a large Swedish lake (345 km 2 ). Acoustic trackin...