Measles is a highly contagious infectious disease and remains a major cause of global morbidity and mortality. Molecular surveillance of measles virus (MV) is used for tracing transmission chains, by, for instance, distinguishing between repeated introductions and endemic circulation. WHO guidelines used in the global measles surveillance network recommend sequencing of a 450-nucleotide region at the C-terminal end of the N-ge...

Migratory animals play a crucial role in connecting distinct habitats by transferring matter and energy across ecosystem boundaries. In the North Atlantic, anadromous species exemplify this through their movement between freshwater and marine environments. Alosids, including species such as alewife ( Alosa pseudoharengus ), blueback herring ( Alosa aestivalis ), and American shad ( Alosa sapidissima ), exhibit this migratory b...

This work focusses on extending the deep compartment model (DCM) framework to the estimation of mixed-effects. By introducing random effects, model predictions can be personalized based on drug measurements, enabling the testing of different treatment schedules on an individual basis. The performance of classical first-order (FO and FOCE) and machine learning based variational inference (VI) algorithms were compared in a simul...

Limited data are available to guide the decision-making process for clinicians and their patients regarding palliative treatment options for patients with isolated synchronous colorectal cancer peritoneal metastases (CRC-PM). Therefore, the aim of this study is to analyze the outcome of the different palliative treatments for these patients. All patients diagnosed with isolated synchronous CRC-PM between 2009 and 2020 (Netherl...

Marine biota are redistributing at a rapid pace in response to climate change and shifting seascapes. While changes in fish populations and community structure threaten the sustainability of fisheries, our capacity to adapt by tracking and projecting marine species remains a challenge due to data discontinuities in biological observations, lack of data availability, and mismatch between data and real species distributions. To...