P. Kramer results 67
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Biodiversity is highly heterogeneous across space, shaped by factors such as climate, geographical distance, and human activities. However, as we enter the Anthropocene, the impacts of habitat loss and fragmentation on biodiversity are becoming increasingly severe and insufficiently disentangled. Here we assess how habitat amount, habitat fragmentation, regional climate, and geographical distance influence beta diversity and e...
Pathogens in the garden dormouse Eliomys quercinusNARA Subscribed
Wild rodents are important reservoirs and vectors of various pathogens, and play a crucial role in the spread of zoonotic pathogens. The garden dormouse ( Eliomys quercinus ), an arboreal nocturnal rodent species native to Europe, has declined throughout much of its natural range in recent decades. The reason for this ongoing decline is not yet fully understood, but infectious diseases may play a role. This study aimed to revi...
Species interactions structure ecological communities through direct and indirect pathways with ecosystem‐wide implications. Despite mounting interest in the importance of indirect interactions, empirical evidence remains limited. Here, we demonstrate the critical role of parasite‐mediated competition in driving community outcomes in a multi‐species system of conservation and management concern. We leveraged 2 years of detecti...
Survival and cause‐specific mortality rates are vital for evidence‐based population forecasting and conservation, particularly for large carnivores, whose populations are often vulnerable to human‐caused mortalities. It is therefore important to know the relationship between anthropogenic and natural mortality causes to evaluate whether they are additive or compensatory. Further, the relation between survival and environmental...
Evaluation of BRCA1/2 testing rates in epithelial ovarian cancer patients: lessons learned from real-world clinical dataNARA Subscribed
Identification of somatic and germline BRCA1/2 pathogenic variants in epithelial ovarian cancer (EOC) patients is essential for determining poly-(ADP-ribose)-polymerase (PARP) inhibitor sensitivity and genetic predisposition. In the Netherlands, BRCA1/2 testing changed to a tumor-first approach to efficiently identify both somatic and germline pathogenic variants in all patients. Here, we performed an in-depth evaluation of th...
Source tracing of Anthonomus grandis captured in areas of the USA where the species had previously been eradicatedNARA Subscribed
Anthonomus grandis Boheman (Coleoptera: Curculionidae) is comprised of two subspecies: the boll weevil ( A. g. grandis ) and the thurberia weevil ( A. g. thurberiae ). The thurberia weevil is generally regarded as a non-pest variant of the species, whereas the boll weevil is an important economic pest of commercial cotton. In the USA, a nationwide eradication program has been largely successful against the boll weevil, but rei...
Validation of global ionospheric models using long-term observations of pulsar Faraday rotation with the LOFAR radio telescopeNARA Subscribed
Broad band pulsar radiation can be effectively used to monitor the properties of the magneto-ionic media through which it propagates. Faraday rotation calculated from polarised pulsar observations provides an integrated product of electron densities and the line-of-sight component of the magnetic field in the intervening plasma. In particular, a time-variable effect mainly associated with the rapidly changing column density of...
Establishing resilience in times of climate change—a perspective on humans and buildingsNARA Subscribed
With a contribution of 40% to the annual global CO 2 -emissions, the built environment needs to drastically reduce its impact, while also providing pleasant and healthy indoor spaces and protecting people from weather extremes. Over time, particularly in western and industrialized countries, buildings have evolved to shield occupants almost completely from outdoor conditions. As a consequence, humans have become so used to a c...
Biotic homogenization and differentiation of plant communities in tropical and subtropical forestsNARA Subscribed
Anthropogenic impacts on biodiversity can lead to biotic homogenization (BH) and biotic differentiation (BD). BH is a process of increasing similarity in community composition (including taxonomic, functional, and phylogenetic components), whereas BD is a process of decreasing similarity over space and time. Here, we conducted a systematic review of BH and BD in plant communities in tropical and subtropical forests to identify...
The determination of a tailored anti-drug antibody (ADA) testing strategy is based on the immunogenicity risk assessment to allow a correlation of ADAs with changes to pharmacokinetics, efficacy, and safety. The clinical impact of ADA formation refines the immunogenicity risk assessment and defines appropriate risk mitigation strategies. Health agencies request for high-risk biotherapeutics to extend ADA monitoring for patient...
A Modular Workflow for Model Building, Analysis, and Parameter Estimation in Systems Biology and NeuroscienceNARA Subscribed
Neuroscience incorporates knowledge from a range of scales, from single molecules to brain wide neural networks. Modeling is a valuable tool in understanding processes at a single scale or the interactions between two adjacent scales and researchers use a variety of different software tools in the model building and analysis process. Here we focus on the scale of biochemical pathways, which is one of the main objects of study...