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Defining an ageing-related pathology, disease or syndrome: International Consensus StatementNARA Subscribed
Around the world, individuals are living longer, but an increased average lifespan does not always equate to an increased health span. With advancing age, the increased prevalence of ageing-related diseases can have a significant impact on health status, functional capacity and quality of life. It is therefore vital to develop comprehensive classification and staging systems for ageing-related pathologies, diseases and syndrom...
John Squire did not only produce leading works in the muscle field, he also significantly contributed to the vascular permeability field by ultrastructural analysis of the endothelial glycocalyx. Presented here is a review of his involvement in the field by his main collaborator C.C. Michel and his last postdoctoral researcher KP Arkill. We end on a reinterpretation of his work that arguably links to our current understanding...
We present a new chronology to constrain ice‐margin retreat in the northern Irish Sea Basin. Estimates on the timing of ice thinning derived from surface exposure ages for boulders from the summits of the Isle of Man and south‐west Cumbria suggest that ice thinning was commensurate with the rapid retreat that followed the short‐lived advance of the Irish Sea Ice Stream (ISIS) to maximum limits in the Celtic Sea. This ice retre...
Summary The ecological functions of many toxins continue to remain unknown for those produced by environmental pathogens. Mycobacterium ulcerans , the causative agent of the neglected tropical disease, Buruli ulcer, produces a cytotoxic macrolide, mycolactone, whose function(s) in the environment remains elusive. Through a series of dual‐choice behaviour assays, they show that mycolactone may be an interkingdom cue for the yel...
Animals can be important in modulating ecosystem‐level nutrient cycling, although their importance varies greatly among species and ecosystems. Nutrient cycling rates of individual animals represent valuable data for testing the predictions of important frameworks such as the Metabolic Theory of Ecology ( MTE ) and ecological stoichiometry ( ES ). They also represent an important set of functional traits that may reflect both...
Denitrification alternates between a source and sink of nitrous oxide in the hypolimnion of a thermally stratified reservoirNARA Subscribed
Nitrogen loading from developed watersheds to aquatic ecosystems can stimulate microbial denitrification, a process that reduces nitrate (NO − 3 ) to dinitrogen (N 2 ) or nitrous oxide (N 2 O), the latter a potent greenhouse gas. While aquatic ecosystems are a globally significant source of N 2 O to the atmosphere, the relationship between denitrification and N 2 O production is not well known. Until recently, this field of re...
Site‐level evaluation of satellite‐based global terrestrial gross primary production and net primary production monitoringNARA Subscribed
Operational monitoring of global terrestrial gross primary production (GPP) and net primary production (NPP) is now underway using imagery from the satellite‐borne Moderate Resolution Imaging Spectroradiometer (MODIS) sensor. Evaluation of MODIS GPP and NPP products will require site‐level studies across a range of biomes, with close attention to numerous scaling issues that must be addressed to link ground measurements to the...
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