P. Lee results 1,100
· Newest (Page 1/44, per page 25)
Author: P. Lee ×Clear All Filters
Search Results
Development of RS1-specific ACMG/AMP variant classification criteria with pilot variant curationNARA Subscribed
Gene-based therapies are being developed for retinal diseases, including RS1- related X-linked retinoschisis. Therefore it is essential to determine which variants are pathogenic and which are benign when enrolling patients. The Clinical Genome Resource (ClinGen) X-Linked Inherited Retinal Diseases (XLRD) Variant Curation Expert Panel (VCEP) brings together clinician scientists, molecular biologists, and geneticists to apply t...
Anthropogenic Effects, Not Climatic Factors, Are Correlated With Holocene Population Expansion of an Insular Bee FaunaNARA Subscribed
Aim Remote island systems with small landmasses and reliable estimates of human occupancy can be ideal models to disentangle the roles of global climatic changes and local human occupation on biota. Here, we explored this with demographic reconstructions of native, ground‐nesting bees with non‐specialised floral visitation habits to infer changes in effective population size ( N e ). Location Viti Levu, Fiji, South West Pacifi...
Microfluidic Precision Engineered Artificial GARP Presenting Cells for Regulatory T-Cell InductionNARA Subscribed
Purpose The incidence of autoimmune diseases has increased in Western societies, highlighting the need for novel treatment strategies. Current therapies, including biologics, are limited by high costs, potential adverse effects, and often lack specificity and long-term efficacy. Regulatory T cells (Tregs) are crucial for maintaining immune tolerance and represent a promising target for autoimmune disease therapies. However, cu...
An increasing number of systematic reviews and meta-analyses examine health outcomes from traumatic brain injury (TBI). This umbrella review examines the association of TBI with comorbid health outcomes and evaluates the methodological rigor of existing literature. This protocol was registered with the International Prospective Register of Systematic Reviews (PROSPERO; Registration No. CRD42024581341). EMBASE, PubMed, MEDLINE,...
Electronic cigarette (e-cigarette) use continues to rise, yet the toxicological mechanisms by which inhaled aerosols impair airway epithelial integrity remain poorly defined. E-cadherin, a key adherens junction protein required for epithelial cohesion, can undergo proteolytic cleavage to generate soluble E-cadherin (sE-cad), a mediator of epithelial barrier dysfunction and inflammation. We hypothesized that e-cigarette aerosol...
The urinary bladder is innervated by two anatomically distinct populations of sensory neurons originating from dorsal root ganglia (DRG): one from the thoracolumbar (TL) and another from the lumbosacral (LS) spinal region. While we previously characterized the morphology and distribution of sensory endings arising from LS DRG, the terminals of TL afferents remain undefined. In this study, we employed anterograde neuronal traci...