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Springer Nature4
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✓Purinergic Signalling4
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P. Lin results 4 · Newest (Page 1/1, per page 25)
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Journal: Purinergic Signalling ×Author: P. Lin ×Clear All Filters
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Structural basis for the functional properties of the P2X7 receptor for extracellular ATPNARA Subscribed
Purinergic Signalling · 2021 · Vol. 17 · Issue 3 · Springer
Lin-Hua Jiang; Emily A. Caseley; Steve P. Muench; Sébastien Roger
The P2X7 receptor, originally known as the P2Z receptor due to its distinctive functional properties, has a structure characteristic of the ATP-gated ion channel P2X receptor family. The P2X7 receptor is an important mediator of ATP-induced purinergic signalling and is involved the pathogenesis of numerous conditions as well as in the regulation of diverse physiological functions. Functional characterisations, in conjunction w...
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Contribution of Val/Ile87 residue in the extracellular domain in agonist-induced current responses of the human and rat P2X7 receptorsNARA Subscribed
Purinergic Signalling · 2020 · Vol. 16 · Issue 4 · Springer
Emily A Caseley; Stephen P Muench; Lin-Hua Jiang
The P2X7 receptor (P2X7R) is an ATP-gated cation channel with a critical role in many physiological and pathological processes, and shows prominent functional differences across mammalian species, exemplified by larger current responses of the rat (r) P2X7R to ATP and its analogue BzATP and a greater sensitivity to agonists compared with the human (h) P2X7R. Here, we showed that substitution of Val87 residue in the extracellul...
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Conformational changes during human P2X7 receptor activation examined by structural modelling and cysteine-based cross-linking studiesNARA Subscribed
Purinergic Signalling · 2017 · Vol. 13 · Issue 1 · Springer
Emily A Caseley; Stephen P Muench; Lin-Hua Jiang
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Loss of apical monocilia on collecting duct principal cells impairs ATP secretion across the apical cell surface and ATP-dependent and flow-induced calcium signalsNARA Subscribed
Purinergic Signalling · 2008 · Vol. 4 · Issue 2 · Springer
Michael B. Hovater; Dragos Olteanu; Elizabeth L. Hanson; Nai-Lin Cheng; Brian Siroky; Attila Fintha; Peter Komlosi; Wen Liu; Lisa M. Satlin; P. Darwin Bell; Bradley K. Yoder; Erik M. Schwiebert
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