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Contractile effects of stimulation of D1-dopamine receptors in the isolated human atriumNARA Subscribed
Dopamine receptors have been claimed not to directly increase contractility in the human heart. Therefore, we performed contraction experiments in isolated electrically driven human atrial preparations (HAP). For comparison, we performed contraction experiments with left atrial preparations of transgenic mice which harbor a cardiac overexpression of human D 1 -dopamine receptors (D 1 -TG). In D 1 -TG, first we noted that dopam...
Studies on the mechanisms of action of MR33317NARA Subscribed
MR33317 was synthesized as an acetylcholinesterase-inhibitor and an agonist at brain 5-HT 4 -receptors. MR33317 might be used to treat Morbus Alzheimer. This therapeutic action of MR33317 might be based on MR33317´s dual synergistic activity. We tested the hypothesis that MR33317 also stimulates 5-HT 4 -receptors in the heart. MR33317 (starting at 10 nM) increased force of contraction and beating rate in isolated atrial prepar...
Population genetics and demography of the endemic mouse species of Cyprus, Mus cypriacusNARA Subscribed
Mus cypriacus is one of three small palaeoendemic mammals that have survived the Mediterranean islands’ anthropization. This species, endemic to Cyprus, was described in 2006 and stands out as one of the last mammal species to have been discovered in Europe. Despite scarce data on its genetics, ecology, and life-history traits, Mus cypriacus is assessed as Least Concern LC in the IUCN Red List, partly due to its morphological...
After drought events, tree recovery depends on sufficient carbon (C) allocation to the sink organs. The present study aimed to elucidate dynamics of tree‐level C sink activity and allocation of recent photoassimilates (C new ) and stored C in c. 70‐year‐old Norway spruce ( Picea abies ) trees during a 4‐week period after drought release. We conducted a continuous, whole‐tree 13 C labeling in parallel with controlled watering a...
Prolonging survival in good health is a fundamental societal goal. However, the leading determinants of disability-free survival in healthy older people have not been well established. Data from ASPREE, a bi-national placebo-controlled trial of aspirin with 4.7 years median follow-up, was analysed. At enrolment, participants were healthy and without prior cardiovascular events, dementia or persistent physical disability. Disab...
High resilience of carbon transport in long‐term drought‐stressed mature Norway spruce trees within 2 weeks after drought releaseNARA Subscribed
Under ongoing global climate change, drought periods are predicted to increase in frequency and intensity in the future. Under these circumstances, it is crucial for tree's survival to recover their restricted functionalities quickly after drought release. To elucidate the recovery of carbon (C) transport rates in c. 70‐year‐old Norway spruce ( Picea abies [L.] KARST .) after 5 years of recurrent summer droughts, we conducted...
The degree to which Southern Hemisphere climatic changes during the end of the last glacial period and early Holocene (30‐8 ka) were influenced or initiated by events occurring in the high latitudes of the Northern Hemisphere is a complex issue. There is conflicting evidence for the degree of hemispheric ‘teleconnection’ and an unresolved debate as to the principle forcing mechanism(s). The available hypotheses are difficult t...
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