P. Reid results 189
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Interpretable deep learning reveals spatiotemporal MRI features of brain aging that align with neurodegenerationNARA Subscribed
Cortical thinning and atrophy are hallmarks of brain aging that have been characterized using magnetic resonance imaging (MRI). Brain aging involves many neuroanatomic features whose effects on brain structure remain unexplored. To address this challenge, we trained interpretable deep neural networks (DNNs) to estimate brain age (BA) from T 1 -weighted ( T 1 w) MRI. By identifying MRI features unapparent to humans, DNNs can fi...
SNAPSHOT USA 2024: Year 6 of the Coordinated National Camera Trap Survey of the United StatesNARA Subscribed
Motivation SNAPSHOT USA is an annual, multi‐contributor camera trap survey of mammals across the United States. The growing SNAPSHOT USA dataset is intended for tracking the spatial and temporal responses of mammal populations to changes in land use, land cover and climate. These data will be useful for exploring the drivers of spatial and temporal changes in relative abundance and distribution, as well as the impacts of speci...
What’s inside the net? insights into fish bycatch diversity in the Antarctic krill fisheryNARA Subscribed
An ecosystem-based approach to fishery management requires, inter alia, knowledge of fishery impacts on both target and non-target species, as well as the wider ecosystem. To support management of the Antarctic krill fishery, we present a robust reference dataset for identifying fish species caught as bycatch. By combining morphological and molecular taxonomic identification, 53 fish species in 44 genera and 11 families were c...
Connectivity is a multifaceted concept that has important implications for the management and conservation of marine and freshwater fishes. We developed a conceptual framework that encompasses multiple, interrelated categories of connectedness, including landscape (e.g., structural, functional) connectivity and ecological (e.g., trophic, genetic, demographic) connectivity, that together shape the flow of organisms, energy and...
Alzheimer’s disease (AD) disproportionately affects women and carriers of the apolipoprotein E ε4 allele (APOE4), yet little is known about how sex and APOE interact to influence white matter (WM) integrity during disease progression. We integrated diffusion MRI and matched blood transcriptomic data to investigate these interactions and their underlying biological mechanisms. WM microstructure was quantified using diffusion te...
Although cratons owe their longevity to thick, depleted and consequently buoyant sub-continental lithospheric mantle, their extents are commonly indicated by the known distribution of crustal rocks. However, the limits of a mapped cratonic area often do not match the seismically imaged thick sub-continental lithospheric mantle roots. New mantle xenolith petrology and geochemistry, combined with continental scale geophysical da...
A quarter of all marine methane, a potent greenhouse gas, is estimated to be hosted in Southern Ocean sediments. Climate change-induced ocean warming and ice shelf melting risk the stability of sedimentary gas hydrates, resulting in potential degassing and establishment of marine methane seeps. While methane seeps can originate from various sources, the destabilisation of gas hydrates may contribute to the formation and persis...
Tail-less precursors in synthetic cannabinoid production: investigating a clandestine laboratory, seized samples, and CB1 activityNARA Subscribed
An emerging new trend reveals that potent synthetic cannabinoid receptor agonists (SCRAs) that were prevalent prior to the Chinese class-wide ban in July 2021 have remained on the market or re-emerged. This is likely because of a new production route where unscheduled tail-less precursors are converted into the desired controlled SCRA via a one-step synthesis. This study reports the discovery of a clandestine production site i...
The importance of connectivity for freshwater organisms is widely recognised, yet in‐stream barriers associated with population declines and increased risk of extinction remain globally ubiquitous. Despite their negative consequences, these barriers can protect aquatic communities by limiting the spread of invasive species, leading to conflicting management goals in some regions. Selective fish passage is a solution for the co...
Predicting the progression of MCI and Alzheimer’s disease on structural brain integrity and other features with machine learningNARA Subscribed
Machine learning (ML) on structural MRI data shows high potential for classifying Alzheimer’s disease (AD) progression, but the specific contribution of brain regions, demographics, and proteinopathy remains unclear. Using Alzheimer’s Disease Neuroimaging Initiative (ADNI) data, we applied an extreme gradient-boosting algorithm and SHAP (SHapley Additive exPlanations) values to classify cognitively normal (CN) older adults, th...
Objective Inhaled drug delivery systems need to ensure that the delivered aerosol effectively reach the lungs while overcoming challenges related to environmental conditions, such as relative humidity (RH). This study investigates the impact of environmental factors on aqueous aerosol behaviour using a Respimat® Soft Mist Inhaler (SMI) formulated with and without ethanol content. Methods Comparative Hygroscopic Aerosol Particl...
Marine Ecosystem-Based Management (EBM) approaches are a well-established and fundamental component of international agreements and treaties, regional seas conventions, assessment strategies, European Directives and national and regional instruments. However, there is the need to interrogate and clarify the implementation of EBM approaches under current marine management. Although particular focus here is within the European U...
Solar-powered pumping at a remote denitrifying bioreactorNARA Subscribed
SNAPSHOT USA 2019–2023: The First Five Years of Data From a Coordinated Camera Trap Survey of the United StatesNARA Subscribed
Motivation SNAPSHOT USA is an annual, multicontributor camera trap survey of mammals across the United States. The growing SNAPSHOT USA dataset is intended for tracking the spatial and temporal responses of mammal populations to changes in land use, land cover and climate. These data will be useful for exploring the drivers of spatial and temporal changes in relative abundance and distribution, as well as the impacts of specie...
The Canadian Prairies are one of the major agricultural regions of the world in terms of cereal, oilseed and pulse crop production. With few exceptions, major insect pests like grasshoppers, flea beetles, Lygus bugs, wireworms and pea leaf weevils are controlled with insecticides. Wheat stem sawfly is managed through host plant resistance and endemic natural enemies, whereas cereal leaf beetle is managed through classical biol...