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Gene-environment interactions, leading to immune-brain cross-talk and neuroinflammation are increasingly recognised in neurodevelopmental disorders (NDDs), such as autistic regression and paediatric acute onset neuropsychiatric syndrome (PANS). Nonsteroidal anti-inflammatory drugs, including ibuprofen, provides relief to some neuropsychiatric symptoms, however, the therapeutic mechanisms are unclear. We describe the benefit of...
Tenacibaculosis, a disease caused by Tenacibaculum spp., is of concern in British Columbia (BC, Canada) due to the potential for interspecific transmission from Atlantic salmon ( Salmo salar L.) to Pacific salmon. However, the susceptibility of most Pacific salmonids remains unknown. In this study, Atlantic salmon post‐smolts were bath‐exposed to an Atlantic salmon‐derived BC isolate of Tenacibaculum maritimum (isolate 2.1C) a...
Dryland ecosystems cover 41% of Earth's land surfaces, account for 44% of cultivated lands and 60% of food sources, and make large contributions to the global water and carbon cycles. However, these ecosystems are experiencing unprecedented extremes including heatwaves, floods, and droughts as well as hotter temperatures and often declining water resource availability. These ecosystems are some of the most challenging to monit...
Electronic cigarette (e-cigarette) use continues to rise, yet the toxicological mechanisms by which inhaled aerosols impair airway epithelial integrity remain poorly defined. E-cadherin, a key adherens junction protein required for epithelial cohesion, can undergo proteolytic cleavage to generate soluble E-cadherin (sE-cad), a mediator of epithelial barrier dysfunction and inflammation. We hypothesized that e-cigarette aerosol...
Interpretable deep learning reveals spatiotemporal MRI features of brain aging that align with neurodegenerationNARA Subscribed
Cortical thinning and atrophy are hallmarks of brain aging that have been characterized using magnetic resonance imaging (MRI). Brain aging involves many neuroanatomic features whose effects on brain structure remain unexplored. To address this challenge, we trained interpretable deep neural networks (DNNs) to estimate brain age (BA) from T 1 -weighted ( T 1 w) MRI. By identifying MRI features unapparent to humans, DNNs can fi...
Advancing Our Understanding of CE Loop Strategies: A Synthesizing Framework for Durable Consumer ProductsNARA Subscribed
The Circular Economy (CE) concept is widely promoted as a pathway to sustainability, yet its practical realization can appear to be challenging and unclear due to divergent definitions, interpretations and understanding about the implications and goals of a realized CE. Addressing this gap, this study develops the Circular Economy Loop Strategies (CELS) Framework, a synthesizing foundational model that defines and organizes fi...
Paleoenvironments of the Late Quaternary Tonica thermokarst lake, northeastern Illinois, USA, and an extinct elk‐moose ( Cervalces )NARA Subscribed
The Tonica Depression (TD), a late Quaternary sediment‐filled basin in northeastern Illinois, formed as a thermokarst lake as evidenced by a basal trash layer, its depositional history, and its occurrence on a late‐Pleistocene permafrost landscape. Stratigraphy and radiocarbon ages reveal that a multiproxy paleoenvironmental record extends throughout the late Wisconsin. Burning of organically enriched sediments has abbreviated...
Alzheimer’s disease (AD) disproportionately affects women and carriers of the apolipoprotein E ε4 allele (APOE4), yet little is known about how sex and APOE interact to influence white matter (WM) integrity during disease progression. We integrated diffusion MRI and matched blood transcriptomic data to investigate these interactions and their underlying biological mechanisms. WM microstructure was quantified using diffusion te...
The design and implementation of a smart home for water conservation with onsite rainwater harvestingNARA Subscribed
Sustainable, reliable, and equitable delivery of potable water to all individuals is critical for maintaining a healthy and stable society. Communities across the globe are increasingly struggling to meet potable water demand due to growing populations, increased standards of living, and increasing use in agriculture and industry. Additionally, diminished supply and potential damage resulting from natural disasters with greate...
Objective This study investigated how cumulative environmental exposures influence offspring behaviour and inflammation-related molecular signatures in the brain and peripheral immune system. Methods A novel "triple-hit" mouse model was developed using C57Bl/6JAusB mice (N = 70), combining preconceptual social stress, antenatal high-fat diet, and a postnatal immune challenge (poly(I:C), 10 mg/kg). At 12 weeks, offspring underw...