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The safety of using ethanol-based products for hygienic hand disinfection in healthcare workers is controlled by restricting air levels. This raises the question of whether these workers are sufficiently protected against potential dermal absorption. The study aim was to determine the contribution of the dermal route to the total uptake of ethanol. A laboratory-controlled study of 25 sequential alcohol-based-hand-rubs (ABHRs)...
Instability and blood flow restriction: do they contribute to resistance training adaptations?NARA Subscribed
The aim of this study was to investigate changes in muscle size, strength, and dynamic balance after resistance training on an unstable surface with and without blood flow restriction and on a stable surface. Twenty-nine untrained men were assigned according to baseline vastus lateralis muscle thickness to one of the three resistance training groups: stable surface (TRAD), unstable surface (UST), and unstable surface with bloo...
Interpretable deep learning reveals spatiotemporal MRI features of brain aging that align with neurodegenerationNARA Subscribed
Cortical thinning and atrophy are hallmarks of brain aging that have been characterized using magnetic resonance imaging (MRI). Brain aging involves many neuroanatomic features whose effects on brain structure remain unexplored. To address this challenge, we trained interpretable deep neural networks (DNNs) to estimate brain age (BA) from T 1 -weighted ( T 1 w) MRI. By identifying MRI features unapparent to humans, DNNs can fi...
Regulation of chemicals demands assessment of risks rather than identification of hazards onlyNARA Subscribed
This position paper was collaboratively written during the international expert symposium “EU Chemicals Assessment - Risk- or Hazard-based?” that was organised by the German Federal Institute for Risk Assessment (BfR) in Berlin on November 27th and 28th 2025. Twenty experts from several institutions and European countries considered the scientific merits of both hazard-based and risk-based approaches to chemical safety assessm...
Alzheimer’s disease (AD) disproportionately affects women and carriers of the apolipoprotein E ε4 allele (APOE4), yet little is known about how sex and APOE interact to influence white matter (WM) integrity during disease progression. We integrated diffusion MRI and matched blood transcriptomic data to investigate these interactions and their underlying biological mechanisms. WM microstructure was quantified using diffusion te...
WaterLANDS: A Database of Carbon Stocks, GHG Fluxes and Biodiversity Indicators in Restored European WetlandsNARA Subscribed
Motivation Wetland restoration is expected to play an important role in helping Europe achieve its climate and biodiversity targets as stated in the European Green Deal. Restored wetlands sequester atmospheric carbon and provide habitat for a wide range of plant and animal species. To design effective, evidence‐based restoration targets and guide future projects, it is critical to understand the impacts of wetland restoration...
Extreme temperatures, recent warming and seasonal influenza-linking human exposures to respiratory health in southern GermanyNARA Subscribed
Purpose In the context of climate change, extreme ambient temperatures pose a major threat to human health. This study aims to provide detailed insights into how extreme temperatures and potential confounders affect respiratory morbidity. Methods We employed a 14-year time series analysis (2006–2019) in southern Germany, applying penalized distributed lag non-linear models to estimate exposure–response relationships between ex...
Flood events caused by high rainfall can have profound biogeochemical impacts on riverine systems but also on the receiving coastal waters. The winter flood in Germany in December 2023/January 2024 affected the Elbe and Weser River systems. We obtained unique data during the peak of the flood and compared these with the monthly means from previous years (2018-2023). Hydrographic parameters and nutrients were determined by stan...
Motivation Here, we make available a second version of the BioTIME database, which compiles records of abundance estimates for species in sample events of ecological assemblages through time. The updated version expands version 1.0 of the database by doubling the number of studies and includes substantial additional curation to the taxonomic accuracy of the records, as well as the metadata. Moreover, we now provide an R packag...
Predicting the progression of MCI and Alzheimer’s disease on structural brain integrity and other features with machine learningNARA Subscribed
Machine learning (ML) on structural MRI data shows high potential for classifying Alzheimer’s disease (AD) progression, but the specific contribution of brain regions, demographics, and proteinopathy remains unclear. Using Alzheimer’s Disease Neuroimaging Initiative (ADNI) data, we applied an extreme gradient-boosting algorithm and SHAP (SHapley Additive exPlanations) values to classify cognitively normal (CN) older adults, th...
An exploration of the perspectives of Dutch adults experiencing a genetic condition on human germline gene editingNARA Subscribed
Views of people with a genetic condition are crucial in deliberations on human germline gene editing (HGGE), but their perspectives are at risk to be devalued due to epistemic injustice and insufficient attention for the possible sensitivities surrounding HGGE. This study set out to explore the perspectives of people dealing with a genetic condition regarding HGGE, and the possible sensitivities surrounding this topic. We cond...
Migratory Birds Advance Spring Arrival and Egg‐Laying in the Arctic, Mostly by Travelling FasterNARA Subscribed
In the current warming climate, many organisms in seasonal environments advance their timing of reproduction to benefit from resource peaks earlier in spring. For migrants, the potential to advance reproduction may be constrained by their migration strategies, notably their ability to advance arrival at the breeding grounds. Recent studies show various changes in migration strategies, including wintering closer to the breeding...
LandFrag : A Dataset to Investigate the Effects of Forest Loss and Fragmentation on BiodiversityNARA Subscribed
Motivation The accelerated and widespread conversion of once continuous ecosystems into fragmented landscapes has driven ecological research to understand the response of biodiversity to local (fragment size) and landscape (forest cover and fragmentation) changes. This information has important theoretical and applied implications, but is still far from complete. We compiled the most comprehensive and updated database to inves...
Development of Zinc-Containing Chitosan/Gelatin Coatings with Immunomodulatory Effect for Soft Tissue Sealing around Dental ImplantsNARA Subscribed
BACKGROUND: Soft tissue integration (STI) around dental implant abutments is a prerequisite to prevent bacterial invasion and achieve successful dental implant rehabilitation. However, peri-implant STI is a major challenge after dental abutment placement due to alterations in the immune microenvironment upon surgical dental implant installation. METHODS: Based on known immunomodulatory effects of zinc, we herein deposited zinc...