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Understanding adaptation at species' climate limits is key for predicting evolutionary and ecological responses to climate change. In montane environments, warming may drive species distribution shifts, yet the adaptive potential of populations at leading and rear edges remains unclear. Few studies have simultaneously tested both fitness and local adaptation across elevational range limits. We conducted common garden experimen...
Partnership in Cancer Research (PCAR) Program Increases Medical Student Knowledge and Confidence to Perform Cancer ResearchNARA Subscribed
Arkansas has a high cancer burden, and a pressing need exists for more medical students to pursue oncology as a career. The Partnership in Cancer Research (PCAR) program provides a summer research experience at the University of Arkansas for Medical Sciences for 12 medical students who have completed their first year of medical training. A majority of participants spend time pursuing cancer research in basic science, clinical,...
Prolonging survival in good health is a fundamental societal goal. However, the leading determinants of disability-free survival in healthy older people have not been well established. Data from ASPREE, a bi-national placebo-controlled trial of aspirin with 4.7 years median follow-up, was analysed. At enrolment, participants were healthy and without prior cardiovascular events, dementia or persistent physical disability. Disab...
Testing the niche‐breadth–range‐size hypothesis: habitat specialization vs. performance in Australian alpine daisiesNARA Subscribed
Relatively common species within a clade are expected to perform well across a wider range of conditions than their rarer relatives, yet experimental tests of this “niche‐breadth–range‐size” hypothesis remain surprisingly scarce. Rarity may arise due to trade‐offs between specialization and performance across a wide range of environments. Here we use common garden and reciprocal transplant experiments to test the niche‐breadth...
Climate structures genetic variation across a species' elevation range: a test of range limits hypothesesNARA Subscribed
Gene flow may influence the formation of species range limits, and yet little is known about the patterns of gene flow with respect to environmental gradients or proximity to range limits. With rapid environmental change, it is especially important to understand patterns of gene flow to inform conservation efforts. Here we investigate the species range of the selfing, annual plant, Mimulus laciniatus , in the California Sierra...
The range of resources that a species uses (i.e. its niche breadth) might determine the geographical area it can occupy, but consensus on whether a niche breadth–range size relationship generally exists among species has been slow to emerge. The validity of this hypothesis is a key question in ecology in that it proposes a mechanism for commonness and rarity, and if true, may help predict species' vulnerability to extinction....
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