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Total plasma N-glycomic patterns of COVID-19 diseaseNARA Subscribed
Total plasma N -glycans alter in disease states, with few studies focused on COVID-19. A discovery cohort of 310 COVID-19 patients, replicated with 97 COVID-19 patients and tested with 100 COVID-19 patients, was used to unearth the N -glycans capable of distinguishing infection, as well as prognosis of intensive care unit (ICU) admission and mortality. All significant bisected glycans were decreased in patients compared to con...
Antibiotics cause significant gut microbiome dysbiosis, particularly when administered orally. This contributes to antimicrobial resistance (AMR) and is associated with myriad health conditions. Novel drug delivery strategies that minimize gut exposure while maintaining therapeutic efficacy are urgently needed. This study aimed to evaluate whether a novel transdermal system could reduce gut microbiome disruption compared to or...
Interpretable deep learning reveals spatiotemporal MRI features of brain aging that align with neurodegenerationNARA Subscribed
Cortical thinning and atrophy are hallmarks of brain aging that have been characterized using magnetic resonance imaging (MRI). Brain aging involves many neuroanatomic features whose effects on brain structure remain unexplored. To address this challenge, we trained interpretable deep neural networks (DNNs) to estimate brain age (BA) from T 1 -weighted ( T 1 w) MRI. By identifying MRI features unapparent to humans, DNNs can fi...
Oyster Size Distributions Vary Across Time and Space in the Tampa Bay Estuary, 250–2024 ceNARA Subscribed
Aim Restoration benchmarks often assume an undisturbed historic range of variability, if they include historic information at all. However, recent research highlights the need for a more nuanced understanding of shifting baselines and how to best incorporate past variabilities in modern management. We investigate trends in oyster size through time (ca. 250–2024 ce ) and space (ca. 1000 km 2 ) in the Tampa Bay Estuary to unders...