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Mesoporous silica nanoparticles with an azobenzene gatekeeper as hypoxia-responsive nanocarriers for targeted doxorubicin deliveryNARA Subscribed
Hypoxia is a key feature of solid tumors, contributing to therapeutic resistance and poor prognosis. Targeting hypoxic environments presents an opportunity to enhance drug delivery selectivity and improve treatment outcomes. Among nanocarriers, mesoporous silica nanoparticles (MSNs) have demonstrated great potential for drug delivery; however, achieving precise control over drug release remains a challenge. In this work, we de...
Marine megafauna species are affected by a wide range of anthropogenic threats. To evaluate the risk of such threats, species’ vulnerability to each threat must first be determined. We build on the existing threats classification scheme and ranking system of the International Union for Conservation of Nature (IUCN) Red List of Threatened Species by assessing the vulnerability of 256 marine megafauna species to 23 at‐sea threat...
Principal results of the Portoviejo (Ecuador) seismic microzonation project and importance for seismic hazard mitigationNARA Subscribed
The 2016 Mw7.8 Pedernales earthquake caused extensive damage along the central Ecuadorian coastline, resulting in 661 casualties, 4859 injured and the collapse of numerous buildings. The city of Portoviejo (Ecuador), located 140 km from the epicenter, was one of the most severely impacted municipalities with approximately 10% of its buildings damaged and 40 reinforced concrete buildings in the city center collapsed. A seismic...
Impacts of Climate, Organic Management, and Degradation Status on Soil Biodiversity in Agroecosystems WorldwideNARA Subscribed
Unsustainable soil management, climate change, and land degradation jeopardize soil biodiversity and soil‐mediated ecosystem functions. Although the transition from conventional to organic agriculture has been proposed as a potential solution to alleviate these pressures, there is limited evidence of its effectiveness in enhancing belowground biodiversity across different biogeographical regions, climates, and land degradation...
Notes on Towed Self-Propulsion Experiments with Simulated Managed Ice in Traditional Towing TanksOA Marine
Efficiency estimation of a propeller behind a vessel’s hull while sailing through ice floes, together with the ship’s resistance to motion, is a key factor in designing the power plant and determining the safety measures of a ship. This paper encloses the results from the experiments conducted at the CEHINAV towing tank, which consisted of analyzing the influence of the concentration at the free surface of artificial blocks, s...