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Clustering of rheumatoid arthritis patients: an unsupervised machine learning approach for characterizing the TNFi responseNARA Subscribed
This study aimed to identifydistinct profiles of response to Tumor Necrosis Factor inhibitors (TNFi) in rheumatoid arthritis (RA) patients using unsupervised machine learning to integrate clinical, demographic, and genetic data. A cohort of 294 RA patients was analyzed using hierarchical clustering techniques. Data collected included body mass index (BMI), adherence to physical activity, prevalence of comorbidities, seropositi...
Patagonian deglaciation: aquatic macroinvertebrate biodiversity in proglacial and paraglacial pondsNARA Subscribed
Glacier retreat is rapidly transforming cryospheric landscapes with new pond networks establishing in deglaciated landscapes. However, our understanding of the aquatic biodiversity within these rapidly evolving landscapes has been limited, especially in southern Patagonia despite having the largest temperate icefields globally. We examined the aquatic macroinvertebrate diversity in paraglacial forest and proglacial ponds at th...
Marine megafauna species are affected by a wide range of anthropogenic threats. To evaluate the risk of such threats, species’ vulnerability to each threat must first be determined. We build on the existing threats classification scheme and ranking system of the International Union for Conservation of Nature (IUCN) Red List of Threatened Species by assessing the vulnerability of 256 marine megafauna species to 23 at‐sea threat...
● This abstract summarizes the results of two expert consultations conducted to gather insights into effective communication and engagement strategies in recreational fisheries. ● Effective science communication fosters knowledge, understanding, and trust in both science and management decisions. ● Public involvement and stakeholder engagement are essential for effective management. ● Simplifying complex research findings and...
MicroRNA signature from extracellular vesicles of HCV/HIV co-infected individuals differs from HCV mono-infectedNARA Subscribed
Hepatitis C virus (HCV) coinfection with human immunodeficiency virus (HIV) has a detrimental impact on disease progression. Increasing evidence points to extracellular vesicles (EVs) as important players of the host-viral cross-talk. The microRNAs (miRNAs), as essential components of EVs cargo, are key regulators of normal cellular processes and also promote viral replication, viral pathogenesis, and disease progression. We a...
Data capturing multiple axes of tree size and shape, such as a tree's stem diameter, height and crown size, underpin a wide range of ecological research—from developing and testing theory on forest structure and dynamics, to estimating forest carbon stocks and their uncertainties, and integrating remote sensing imagery into forest monitoring programmes. However, these data can be surprisingly hard to come by, particularly for...
Testing a global standard for quantifying species recovery and assessing conservation impactNARA Subscribed
Recognizing the imperative to evaluate species recovery and conservation impact, in 2012 the International Union for Conservation of Nature (IUCN) called for development of a “Green List of Species” (now the IUCN Green Status of Species). A draft Green Status framework for assessing species’ progress toward recovery, published in 2018, proposed 2 separate but interlinked components: a standardized method (i.e., measurement aga...
Extinctions of undiscovered species (undetected extinctions) constitute a portion of biodiversity loss that is often ignored. We compared the performance of 2 models of undetected extinctions – Tedesco and SEUX – when estimating undetected extinctions with both simulated and real‐world data. We generated simulated data by considering a birth‐death process in which less abundant species were more likely to go extinct. When dete...
Climate‐induced changes in the suitable habitat of cold‐water corals and commercially important deep‐sea fishes in the North AtlanticNARA Subscribed
The deep sea plays a critical role in global climate regulation through uptake and storage of heat and carbon dioxide. However, this regulating service causes warming, acidification and deoxygenation of deep waters, leading to decreased food availability at the seafloor. These changes and their projections are likely to affect productivity, biodiversity and distributions of deep‐sea fauna, thereby compromising key ecosystem se...
Simulating rewetting events in intermittent rivers and ephemeral streams: A global analysis of leached nutrients and organic matterNARA Subscribed
Climate change and human pressures are changing the global distribution and the extent of intermittent rivers and ephemeral streams (IRES), which comprise half of the global river network area. IRES are characterized by periods of flow cessation, during which channel substrates accumulate and undergo physico‐chemical changes (preconditioning), and periods of flow resumption, when these substrates are rewetted and release pulse...