NARA Discovery
NARA Subscribed Scholarly Literature Discovery
Boolean search: climate AND coral · microplastic OR nanoplastic · plastic NOT freshwater · "marine heatwave"
Advanced Search
Topic searches article titles and abstracts. Starts a new search; publisher and year refine it.
Searches article titles and abstracts.
Accepts bare DOI, doi: prefix, or a doi.org URL.
Complete publisher name. Publisher imprints are grouped under their main publisher where applicable.
Exact match by full journal title or ISSN.
–
Refine Results Clear Filters
Collection
NARA Subscribed1
Publisher
Springer Nature1
Journal
Pharmaceutical Research1
Publication Year
20201
Parul Pall results 1 · Newest (Page 1/1, per page 25)
Export CSV Export RIS Export current results · up to 5,000 records
Author: Parul Pall ×Clear All Filters
Search Results
Application of Pharmacokinetic-Pharmacodynamic Modeling to Inform Translation of In Vitro NaV1.7 Inhibition to In Vivo Pharmacological Response in Non-human PrimateNARA Subscribed
Pharmaceutical Research · 2020 · Vol. 37 · Issue 10 · Springer
Jeanine E. Ballard; Parul Pall; Joshua Vardigan; Fuqiang Zhao; Marie A. Holahan; Richard Kraus; Yuxing Li; Darrell Henze; Andrea Houghton; Christopher S. Burgey; Christopher Gibson
Purpose This work describes a staged approach to the application of pharmacokinetic-pharmacodynamic (PK-PD) modeling in the voltage-gated sodium ion channel (NaV1.7) inhibitor drug discovery effort to address strategic questions regarding in vitro to in vivo translation of target modulation. Methods PK-PD analysis was applied to data from a functional magnetic resonance imaging (fMRI) technique to non-invasively measure treatm...
View Details View Full Text