Objective and design To define the role of Ten-Eleven Translocation (TET) proteins in Crohn’s disease (CD)-associated inflammation through integrative human and mechanistic studies. Material Publicly available CD transcriptomic and DNA methylation datasets, and primary mononuclear cells and ileal biopsies were analyzed for TET gene expression and signatures. TET1 and TET2 CRISPR/Cas9 knockout macrophage cell lines were generat...