Patrick Jones results 93
· Newest (Page 1/4, per page 25)
Author: Patrick Jones ×Clear All Filters
Search Results
Cytotoxic T-lymphocyte associated protein 4 (CTLA-4) haploinsufficiency is an inborn error of immunity characterized by immune dysregulation, autoimmunity, lymphoproliferation, and an increased risk of malignancy. While susceptibility to oncogenic viral infections has been proposed, the relationship between CTLA-4 haploinsufficiency and human papillomavirus (HPV)-driven carcinogenesis remains poorly characterized. We describe...
Same-same but different: habitat use and partitioning of three cryptobenthic coral reef fishes of the genus TrimmaNARA Subscribed
Partitioning critical resources can alleviate competition among species, allow coexistence, and contribute to biodiversity. The mechanisms driving habitat partitioning within the small-bodied and highly diverse genus Trimma remain unclear. The main aim of this study was to uncover habitat use and partitioning of T. benjamini , T. capostriatum , and T. yanoi that may enable their coexistence on coral reefs in Kimbe Bay, Papua N...
Trophic dynamics of three small and short-lived coral reef fishes of the genus TrimmaNARA Subscribed
Smaller animals may have an enhanced ability to convert microscopic food into biomass, a form of energy that is accessible to larger predators. Small-bodied cryptobenthic reef fishes (CRFs) exploit a variety of small food items and may themselves be important food sources for other coral reef dwellers. However, knowledge regarding the trophic niches of small and abundant CRFs of the genus Trimma is lacking. The aim of this stu...
A primary care pharmacogenetic precision medicine pilot based on specific Māori tribal ethical frameworks and principlesNARA Subscribed
Indigenous tribal communities are frequently underserved by genomic medicine because they are under-represented in research, often live in remote locations and have ethical and cultural perspectives that vary from westernised standpoints. The Rakeiora platform, a permissioning and analytical environment that incorporates Māori perspectives and ethical frameworks on how precision medicine research is best conducted was used to...
Alzheimer’s disease (AD) is characterized by the buildup of extracellular aggregated amyloid-β (Aβ) peptides, following sequential enzymatic cleavage of amyloid precursor protein, along with intraneuronal accumulation of hyperphosphorylated Tau proteins and subsequent neuronal loss. Despite extensive research, the precise mechanisms underlying Aβ and Tau-mediated neurodegeneration remain elusive. Inhibiting protein aggregation...
The microbiome is central to host development and adaptation, yet the balance between vertical and environmental acquisition, and how hosts shape surrounding microbial communities, remains poorly understood. Dung beetles rely on microbial symbionts to extract nutrients from vertebrate dung, with part of their microbiome vertically inherited via a maternal faecal pellet. However, the relative importance of vertical versus horiz...
Growth strategies across life‐history stages and generational turnover of cryptobenthic coral reef fishes of the genus TrimmaNARA Subscribed
Somatic growth influences survival and reproduction, with flow‐on effects on population dynamics and energy fluxes within ecosystems. Small‐bodied cryptobenthic reef fishes may contribute significantly to productivity due to their life‐history traits, including growth rates and rapid generational turnover. However, comprehensive studies on growth that encompass all stages of life are rare. This study aimed to investigate growt...
Motivation Here, we make available a second version of the BioTIME database, which compiles records of abundance estimates for species in sample events of ecological assemblages through time. The updated version expands version 1.0 of the database by doubling the number of studies and includes substantial additional curation to the taxonomic accuracy of the records, as well as the metadata. Moreover, we now provide an R packag...
Combining camera trap surveys and IUCN range maps to improve knowledge of species distributionsNARA Subscribed
Reliable maps of species distributions are fundamental for biodiversity research and conservation. The International Union for Conservation of Nature (IUCN) range maps are widely recognized as authoritative representations of species’ geographic limits, yet they might not always align with actual occurrence data. In recent area of habitat (AOH) maps, areas that are not habitat have been removed from IUCN ranges to reduce commi...
The sense of controlling one’s actions and their consequences is a critical aspect of successful motor activity. While motor performance typically improves with learning, it is unclear whether, how, and why higher order aspects of motor cognition are also affected. Here, we used an implicit measure of sense of agency—the ‘intentional binding’ effect—as participants learned to make a skilled action involving precise control of...
As alien invasive species are a key driver of biodiversity loss, understanding patterns of rapidly changing global species compositions depends upon knowledge of invasive species population dynamics and trends at large scales. Within this context, the Ponto-Caspian region is among the most notable donor regions for aquatic invasive species in Europe. Using macroinvertebrate time series collected over 52 years (1968–2020) at 26...