Pathogenic DEGS1 variants have been reported in individuals with autosomal recessive hypomyelinating leukodystrophy 18 (HLD18; MIM# 618404). Here we describe three participants with HLD features and a previously unreported homozygous DEGS1 5′ splice site variant, c.825+4_825 + 5delAGinsTT (NM_003676.4). We used next-generation DNA and transcriptome sequencing, cell-based splicing assays, and tandem mass spectrometry to detect...

Agricultural soils are increasingly contaminated with microplastics (MPs) and antimicrobial agents, yet the interplay between these pollutants and their effects on soil health, plant growth and development, and microbial communities remains underexplored. Here we investigated the influence of polyamide (PA) microplastics and three prevalent antimicrobials: sulfamethoxazole (SMX), ciprofloxacin (CIP), and triclosan (TCS) on ric...

The forest floor (FF) plays a key role in carbon, nutrient, and water cycling. It is the biologically most active compartment of forest soils, highly responsive to environmental conditions. Yet, its response to current changes in environmental conditions and forest management is understudied. Temperate forests are among the best studied ecosystems globally, providing the necessary ecological and biogeochemical background infor...

This study sought to evaluate the characteristics of clinical-pharmacological (CP) medication reviews conducted by the Institute for Clinical Pharmacology of Hannover Medical School for older, multimorbid, polymedicated insurants of the German statutory health insurance fund Kaufmännische Krankenkasse (KKH). Special emphasis was put on potential sex-specific differences between female and male insurants, prescriptions of poten...

Hayli Gubbi volcano in the Afar Regional State of Ethiopia experienced its first historically documented volcanic eruption on 23 November 2025. The event produced a short-lived sustained eruption column, with ash dispersal and fallout primarily towards the north and east of the volcano, and the formation of two new craters at Hayli Gubbi’s summit. Ash from the northern lobe has a basaltic (trachy)andesitic composition. The eru...

Indigenous tribal communities are frequently underserved by genomic medicine because they are under-represented in research, often live in remote locations and have ethical and cultural perspectives that vary from westernised standpoints. The Rakeiora platform, a permissioning and analytical environment that incorporates Māori perspectives and ethical frameworks on how precision medicine research is best conducted was used to...

This study developed an integrated approach for the sustainable exploitation of the green seaweed Codium sp., cultivated in an integrated multitrophic aquaculture (IMTA) system, as a source of ingredients for functional skin care products. Biomass was extracted following European Union cosmetic regulations using a polarity gradient system, yielding five fractions, and the antioxidant, cytotoxic, anti-inflammatory, photoprotect...

The urgent need for new molecules capable of targeting multidrug-resistant microorganisms has redirected bioprospecting efforts toward less explored marine environments and their associated communities, such as marine mycobiota. This study aimed to evaluate the antimicrobial potential of endophytic fungi isolated from various seaweed species and infer the mechanisms of action and chemical profile of most potent fungal extracts...

Nature-based solutions (NBS) are increasingly promoted in climate adaptation strategies to mitigate flood risks and enhance ecosystem resilience. However, the monitoring and evaluation of such interventions remain a challenge due to resource limitations. This paper evaluates a citizen science-based monitoring approach in the Limb Brook catchment (Sheffield, UK), where public photo submissions were used to assess the effectiven...

Tropical frontiers are undergoing rapid land transformations that threaten biodiversity and ecosystem resilience. Using annual land use and land cover (LULC) data from 1985 to 2022 derived from MapBiomas Collection 8, we assessed cumulative landscape stability across three legally defined protection levels in the Araguaia River Basin, a major South American agricultural frontier. Over the study period, unprotected areas experi...

Capture techniques are widely employed in wildlife monitoring programs, yet confinement and handling may induce transient physiological alterations that complicate interpretation of biochemical parameters. This study evaluated temporal changes in serum lactate and creatine kinase (CK) concentrations in free-living Phrynops geoffroanus captured using funnel traps in southern Brazil. Ten adult turtles (5 males, 5 females) were s...

This study investigated the formation of cordycepin in two Cordyceps militaris strains (DSM23612, DSM1153) and Cordyceps ophioglossoides DSM1206 grown on side-stream of black soldier fly (BSF, Hermetia illucens ) rearing, namely puparia and deceased flies. Preliminary submerged experiments showed that only C. militaris DSM23612 demonstrated notable cordycepin production with deceased BSF being the preferred substrate. After 21...