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Ocean acidification (OA) generally receives far less consideration than other climate stressors and related hazards, such as global warming and extreme weather events. Canada is uniquely vulnerable to OA given its extensive coastal oceans, the oceanographic processes in its three basins, accelerated warming and sea-ice melt, and extensive coastal communities and maritime economic sectors. Canada’s coastline is also home to ext...
Exposure to multiple substances is a challenge for risk evaluation. Currently, there is an ongoing debate if generic “mixture assessment/allocation factors” (MAF) should be introduced to increase public health protection. Here, we explore concepts of mixture toxicity and the potential influence of mixture regulation concepts for human health protection. Based on this analysis, we provide recommendations for research and risk a...
Less is more? A novel method for identifying and evaluating non-informative tracers in sediment source mixing modelsNARA Subscribed
Purpose Accelerated soil erosion poses a global hazard to soil health. Understanding soil and sediment behaviour through sediment fingerprinting enables the monitoring and identification of areas with high sediment delivery. Land-use specific sediment source apportionment is increasingly determined using the Bayesian mixing model MixSIAR with compound-specific stable isotopes (CSSI). Here, we investigate CSSIs of fatty acid (F...
Image-based phenomic prediction can provide valuable decision support in wheat breedingNARA Subscribed
Key message Genotype-by-environment interactions of secondary traits based on high-throughput field phenotyping are less complex than those of target traits, allowing for a phenomic selection in unreplicated early generation trials. Abstract Traditionally, breeders’ selection decisions in early generations are largely based on visual observations in the field. With the advent of affordable genome sequencing and high-throughput...
Low circulating adropin concentrations predict increased risk of cognitive decline in community-dwelling older adultsNARA Subscribed
The secreted peptide adropin is highly expressed in human brain tissues and correlates with RNA and proteomic risk indicators for dementia. Here we report that plasma adropin concentrations predict risk for cognitive decline in the Multidomain Alzheimer Preventive Trial (ClinicalTrials.gov Identifier, NCT00672685; mean age 75.8y, SD = 4.5 years, 60.2% female, n = 452). Cognitive ability was evaluated using a composite cognitiv...
Opinion on acetaldehyde as a flavouring substance: considerations for risk assessment Acetaldehyde occurs naturally in many foods and is also used as a flavouring due to its fruity aroma. The International Agency for Research on Cancer (IARC) classified acetaldehyde as possibly carcinogenic to humans and, in combination with oral intake via alcoholic beverages, as carcinogenic to humans. Therefore, the question arises whether...
Methane (CH 4 ), a potent greenhouse gas, is the second most important greenhouse gas contributor to climate change after carbon dioxide (CO 2 ). The biological emissions of CH 4 from wetlands are a major uncertainty in CH 4 budgets. Microbial methanogenesis by Archaea is an anaerobic process accounting for most biological CH 4 production in nature, yet recent observations indicate that large emissions can originate from oxyge...
Contribution to the ongoing discussion on fluoride toxicityNARA Subscribed
Since the addition of fluoride to drinking water in the 1940s, there have been frequent and sometimes heated discussions regarding its benefits and risks. In a recently published review, we addressed the question if current exposure levels in Europe represent a risk to human health. This review was discussed in an editorial asking why we did not calculate benchmark doses (BMD) of fluoride neurotoxicity for humans. Here, we add...
Recently, epidemiological studies have suggested that fluoride is a human developmental neurotoxicant that reduces measures of intelligence in children, placing it into the same category as toxic metals (lead, methylmercury, arsenic) and polychlorinated biphenyls. If true, this assessment would be highly relevant considering the widespread fluoridation of drinking water and the worldwide use of fluoride in oral hygiene product...
Generation of Priority Research Questions to Inform Conservation Policy and Management at a National LevelNARA Subscribed
Integrating knowledge from across the natural and social sciences is necessary to effectively address societal tradeoffs between human use of biological diversity and its preservation. Collaborative processes can change the ways decision makers think about scientific evidence, enhance levels of mutual trust and credibility, and advance the conservation policy discourse. Canada has responsibility for a large fraction of some ma...
Poster abstractsNARA Subscribed
CO 2 ‐mediated changes in aspen chemistry: effects on gypsy moth performance and susceptibility to virusNARA Subscribed
We investigated the effects of long‐term CO 2 enrichment on foliar chemistry of quaking aspen ( Populus tremuloides ) and the consequences of chemical changes for performance of the gypsy moth ( Lymantria dispar ) and susceptibility of the gypsy moth to a nucleopolyhedrosis virus (NPV). Foliage was collected from outdoor open‐top chambers and fed to insects in a quarantine rearing facility. Under enriched CO 2 , levels of leaf...
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