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Impact of Time, Temperature, and Conformational Changes on the Characterization of Cardiotonic Steroid–Na+/K+-ATPase InteractionsNARA Subscribed
Cardiotonic steroids (CTS) have gained prominence due to various mechanisms of action proposed or demonstrated to explain their effects, including their known classical and non-classical signaling pathways mediated by Na + /K + -ATPase (NKA) binding. For the characterization, interaction kinetics have been used to better translate in vivo efficacy and selectivity. In addition, temperature effects assessed by thermodynamic anal...
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