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Unveiling Unusual Ecofunctional Traits of Endozoicomonas Species Through Comprehensive Comparative GenomicsNARA Subscribed
Endozoicomonas is an omnipresent marine bacterial genus, associated with various marine organisms, that contributes to host health, nutrient cycling and disease resistance. Nonetheless, its genomic features remain poorly characterised due to a paucity of high‐quality genomes. In this study, we sequenced 5 novel Endozoicomonas strains and re‐sequenced 1 known strain to improve genomic resolution. By integrating these 6 high‐qua...
ONC201 exerts oncogenic effects beyond its mitochondria-disturbing role in neuroblastoma subsetsNARA Subscribed
Neuroblastoma (NB) is a formidable challenge in pediatric oncology due to its intricate molecular landscape, necessitating multifaceted therapeutic approaches. ONC201 is an imipridone antibiotic compound with a promising drug candidate leveraging its potent anticancer properties against the mitochondrial proteases ClpP and ClpX. Despite demonstrating early clinical promise, particularly in MYCN -amplified NB, its efficacy in n...