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The UK livestock sector faces complex social, economic, political and environmental challenges, requiring approaches for exploring trade-offs and resilience across a range of plausible futures. To address these challenges, this study develops the UK Livestock Shared Socioeconomic Pathways (UK-Livestock-SSPs)—five scenarios extending to 2100—through an iterative, stakeholder-driven co-design process that incorporates UK livesto...
Acorn woodpeckers alter resource use, group size, and spring productivity across an urban landscapeNARA Subscribed
Access to suitable resources shapes the evolution and maintenance of avian cooperative breeding by influencing whether an individual will have a greater chance of survival and reproduction by dispersing or remaining on a natal territory. Cooperatively-breeding species exhibit altered dispersal according to food availability and habitat quality, but the relationship between resource use, group size, and reproduction in human-al...
β1- and β2-adrenergic receptor mediated spontaneous contractions and ryanodine receptor channel opening in human failing heartNARA Subscribed
In heart failure, β-adrenergic receptor (β-AR)-Gsα-cAMP-protein kinase A (PKA) signalling predisposes to delayed-afterdepolarisation-mediated arrhythmias. Phosphodiesterases (PDEs) hydrolyse cAMP, and PDE3 restrains β 1 -AR, β 2 -AR-mediated inotropic responses in failing hearts from β-blocker-treated patients. Whether these receptors provoke arrhythmias through ryanodine receptor (RyR2) dysregulation, and how PDE activity and...
How to Close Nutrient Cycles in Agriculture? Emission reduction potential of different technologies on an EU scaleNARA Subscribed
Sustainable agricultural intensification is essential to feed the growing global population with limited resources. However, agriculture contributes significantly to environmental issues, such as greenhouse gas (GHG) emissions and eutrophication. Optimizing nutrient use is key to improving agricultural productivity while mitigating environmental harm. This study examines the potential of innovative mitigation technologies at t...
Motivation The database initiated by the Mountain Invasion Research Network (MIREN) is one of the few globally implemented standardized vegetation surveys in mountains. The focus is on collecting plant species occurrences at 5‐year intervals along and adjacent to mountain roads spanning elevational gradients, with the goal of providing critical information about the ongoing spread of non‐native plants and the potential impacts...
Resident and Migratory Falcons' Breeding Phenology and Productivity Respond Differently to Weather and Climate Change Across the ArcticNARA Subscribed
Climate change is disproportionately warming the Arctic, leading to changes in weather patterns that affect breeding phenology for many Arctic species. Despite extensive research on non‐predatory birds, few studies have examined the impacts of climate change on higher trophic levels, especially those comparing breeding phenology and productivity between migratory and resident species. Our study used long‐term monitoring data f...
TEAD inhibitor induced switch in energy metabolism drives human podocyte injury in vitroNARA Subscribed
Early detection and understanding of the potential adverse effects of a drug candidate is of utmost importance to reduce the attrition rate during drug development while delivering safe medications to patients. The kidney is one of the most frequently challenged organs involved in drug-induced toxicity, including general glomerulopathy and podocyte- specific cytotoxicity with ensuing overt proteinuria. Whilst TEAD inhibitors a...
Stomatal Decoupling From Photosynthesis Under High Temperatures Is Consistent With Stomatal OptimisationNARA Subscribed
Stomatal pores on plant leaves regulate the gain of carbon through photosynthesis and the loss of water through transpiration. Through their responses to environmental conditions, stomata can constrain plant productivity and transpiration fluxes, exerting a strong control on climate feedbacks over land. Although mechanistic modelling of stomata remains a challenge, semi‐empirical and optimisation models have been successfully...