Peter Cox results 79
· Newest (Page 1/4, per page 25)
Author: Peter Cox ×Clear All Filters
Search Results
Stomatal Decoupling From Photosynthesis Under High Temperatures Is Consistent With Stomatal OptimisationNARA Subscribed
Stomatal pores on plant leaves regulate the gain of carbon through photosynthesis and the loss of water through transpiration. Through their responses to environmental conditions, stomata can constrain plant productivity and transpiration fluxes, exerting a strong control on climate feedbacks over land. Although mechanistic modelling of stomata remains a challenge, semi‐empirical and optimisation models have been successfully...
The Toxicology Investigators Consortium 2024 Annual ReportNARA Subscribed
Limited genomic signatures of population collapse in the critically endangered black abalone ( Haliotis cracherodii )NARA Subscribed
The black abalone, Haliotis cracherodii , is a large, long‐lived marine mollusc that inhabits rocky intertidal habitats along the coast of California and Mexico. In 1985, populations were impacted by a bacterial disease known as withering syndrome (WS) that wiped out >90% of individuals, leading to the closure of all U.S. black abalone fisheries since 1993. Current conservation strategies include restoring diminished populatio...
The Cost of Antivenom: A Cost Minimization Study using the North American Snakebite RegistryNARA Subscribed
Envenomation is a global health issue, with over 9,000 encounters managed in the United States yearly. The introduction of immunoglobulin fragment antivenom has reduced the risk of hypersensitivity. This study compares treatment costs of crotaline envenomation using the Fab and F(ab’) 2 antivenoms as reported to the North American Snakebite Registry (NASBR), a nationwide surveillance tool. Methods This was a retrospective anal...
The Toxicology Investigators Consortium 2023 Annual ReportNARA Subscribed
Objective To determine if and which types of organisational interventions conducted in small and medium size enterprises (SMEs) in healthcare are effective on mental health and wellbeing. Methods Following PRISMA guidelines, we searched six scientific databases, assessed the methodological quality of eligible studies using QATQS and grouped them into six organisational intervention types for narrative synthesis. Only controlle...
Land surface conductance linked to precipitation: Co‐evolution of vegetation and climate in Earth system modelsNARA Subscribed
Vegetation and precipitation are known to fundamentally influence each other. However, this interdependence is not fully represented in climate models because the characteristics of land surface (canopy) conductance to water vapor and CO 2 are determined independently of precipitation. Working within a coupled atmosphere and land modelling framework (CAM6/CLM5; coupled Community Atmosphere Model v6/Community Land Model v5), we...
The Toxicology Investigators Consortium 2022 Annual ReportNARA Subscribed
Ten experiments were conducted to evaluate the efficacy of methods to therapeutically remove fire blight cankers from apple trees with different age, vigor, training system and rootstock combinations in Washington, Oregon, Pennsylvania and New York, United States. Removal methods included pruning at varying distances from visible symptoms, utilization of a sanitizing agent and the use of a stub cut to minimize cankers on struc...
With increasing organic acreage and scrutiny of antibiotics use, alternatives to antibiotics for the control of Erwinia amylovora are of interest to stakeholders. At the same time failures of minimally tested, newly marketed products have resulted in severe infections leading to costly tree and orchard removal. We evaluated antibiotic alternatives in 8 Washington, 3 Oregon, 3 New York and 2 Pennsylvania field experiments condu...
Multiple system atrophy (MSA) is a fatal neurodegenerative disease of unknown etiology characterized by widespread aggregation of the protein alpha-synuclein in neurons and glia. Its orphan status, biological relationship to Parkinson’s disease (PD), and rapid progression have sparked interest in drug development. One significant obstacle to therapeutics is disease heterogeneity. Here, we share our process of developing a clin...
Mangroves provide multiple ecosystem services to coastal communities and their fisheries. In the Galapagos, mangroves have been primarily prized for their role as nursery grounds; though, the importance of cultural benefits, including the development of knowledge systems among fishers, needs to be further explored. Fishers’ local ecological knowledge (LEK) has been employed in the past to answer questions about the marine envi...
Current challenges and opportunities for pharmacogenomics: perspective of the Industry Pharmacogenomics Working Group (I-PWG)NARA Subscribed
Pharmaceutical companies have increasingly utilized genomic data for the selection of drug targets and the development of precision medicine approaches. Most major pharmaceutical companies routinely collect DNA from clinical trial participants and conduct pharmacogenomic (PGx) studies. However, the implementation of PGx studies during clinical development presents a number of challenges. These challenges include adapting to a...
Fluorescence-coupled micropipette aspiration assay to examine calcium mobilization caused by red blood cell mechanosensingNARA Subscribed
Mechanical stimuli such as tension, compression, and shear stress play critical roles in the physiological functions of red blood cells (RBCs) and their homeostasis, ATP release, and rheological properties. Intracellular calcium (Ca 2+ ) mobilization reflects RBC mechanosensing as they transverse the complex vasculature. Emerging studies have demonstrated the presence of mechanosensitive Ca 2+ permeable ion channels and their...