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Prostate cancer radiation therapy shape variation analysisNARA Subscribed
Rationale There is increasing interest in establishing psychedelic research programs at academic medical centers. However, psychedelics are intensely psychoactive, carry considerable sociopolitical baggage, and most are Schedule I drugs, creating significant potential impediments to implementation. There is little formal guidance for investigators on navigating the complex on-the-ground obstacles associated with establishing p...
Radiation therapy is moving from CT based to MRI guided planning, particularly for soft tissue anatomy. An important requirement of this new workflow is the generation of synthetic-CT (sCT) from MRI to enable treatment dose calculations. Automatic methods to determine the acceptable range of CT Hounsfield Unit (HU) uncertainties to avoid dose distribution errors is thus a key step toward safe MRI-only radiotherapy. This work h...
Clinical validation of MR imaging time reduction for substitute/synthetic CT generation for prostate MRI-only treatment planningNARA Subscribed
Radiotherapy treatment planning based only on magnetic resonance imaging (MRI) has become clinically achievable. Though computed tomography (CT) is the gold standard for radiotherapy imaging, directly providing the electron density values needed for planning calculations, MRI has superior soft tissue visualisation to guide treatment planning decisions and optimisation. MRI-only planning removes the need for the CT scan, but re...
Common, low-frequency, rare, and ultra-rare coding variants contribute to COVID-19 severityNARA Subscribed
The combined impact of common and rare exonic variants in COVID-19 host genetics is currently insufficiently understood. Here, common and rare variants from whole-exome sequencing data of about 4000 SARS-CoV-2-positive individuals were used to define an interpretable machine-learning model for predicting COVID-19 severity. First, variants were converted into separate sets of Boolean features, depending on the absence or the pr...
Seasonal habitat drives intestinal microbiome composition in anadromous Arctic char ( Salvelinus alpinus )NARA Subscribed
Summary Intestinal microbial communities from 362 anadromous Arctic char ( Salvelinus alpinus ) from the high Arctic Kitikmeot region, Nunavut, Canada, were characterized using high‐throughput 16S rRNA gene sequencing. The resulting bacterial communities were compared across four seasonal habitats that correspond to different stages of annual migration. Arctic char intestinal communities differed by sampling site, salinity and...
Identification and QTL mapping of resistance to Turnip yellows virus (TuYV) in oilseed rape, Brassica napusNARA Subscribed
Key message Partially dominant resistance to Turnip yellows virus associated with one major QTL was identified in the natural allotetraploid oilseed rape cultivar Yudal. Abstract Turnip yellows virus (TuYV) is transmitted by the peach-potato aphid ( Myzus persicae ) and causes severe yield losses in commercial oilseed rape crops ( Brassica napus ). There is currently only one genetic resource for resistance to TuYV available i...
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