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Temperature alters the inotropic and chronotropic effect of D1-dopamine receptor stimulation in the mammalian atriumNARA Subscribed
We studied how hypothermia and hyperthermia may change the efficacy and/or potency of dopamine to augment the force of contraction in atria of mice with cardiac overexpression of the human D 1 -dopamine receptor (D 1 -TG). We measured the force of contraction on paced (1 Hz) left atria and spontaneously beating right atria of these D 1 -TG mice in vitro. The intrinsic heart beat in the right atria from D 1 -TG mice lowered whe...
This research documents the paleoenvironmental evolution of Eighteen Mile Swamp on North Stradbroke Island (Minjerribah), Australia, from oscillating coastal lagoon into stable freshwater swamp over the last ca. 1600 years. We analyzed multiple sediment cores via physical description, acid sulfate soil assays, particle size analysis, diatom and pollen assemblages, photosynthetic pigment content, and Itrax XRF spectrometry, alo...
OR-1896 ((R)-N-(4-(4-methyl-6-oxo-1,4,5,6-tetrahydropyridazin-3-yl)phenyl)acetamide) is the main active metabolite of levosimendan. However, nobody has reported a positive inotropic effect of OR-1896 in isolated human cardiac preparations. The mechanism of action of OR-1896 remains controversial. Hence, we wanted to know whether OR-1896 exerts a positive inotropic effect in humans and what might be the underlying mechanism. Th...
Life cycle assessment of MHP (Mobile Hydrogen Powersupply), an off-grid system to charge battery electric vehiclesNARA Subscribed
Purpose The paper introduces MHP (Mobile Hydrogen Powersupply), an off-grid fuel cell electric system to recharge (stranded) BEVs, and discusses MHP from the life cycle perspective. The LCA shows the effects of system architecture, charging efficiency, hydrogen supply routes, and the predicted electric vehicle recharging demand on global warming potential and energy consumption and further gives recommendations to optimize the...
Phenotyping in the era of genomics: MaTrics—a digital character matrix to document mammalian phenotypic traitsNARA Subscribed
A new and uniquely structured matrix of mammalian phenotypes, MaTrics ( Ma mmalian Tr aits for Comparative Genom ics ) in a digital form is presented. By focussing on mammalian species for which genome assemblies are available, MaTrics provides an interface between mammalogy and comparative genomics. MaTrics was developed within a project aimed to find genetic causes of phenotypic traits of mammals using Forward Genomics. This...
For the characterization of BOA-OH insensitive plants, we studied the time-dependent effects of the benzoxazolinone-4/5/6/7-OH isomers on maize roots. Exposure of Zea mays seedlings to 0.5 mM BOA-OH elicits root zone-specific reactions by the formation of dark rings and spots in the zone of lateral roots, high catalase activity on root hairs, and no visible defense reaction at the root tip. We studied BOA-6-OH- short-term effe...
Caution, “normal” BMI: health risks associated with potentially masked individual underweight—EPMA Position Paper 2021NARA Subscribed
An increasing interest in a healthy lifestyle raises questions about optimal body weight. Evidently, it should be clearly discriminated between the standardised “normal” body weight and individually optimal weight. To this end, the basic principle of personalised medicine “one size does not fit all” has to be applied. Contextually, “normal” but e.g. borderline body mass index might be optimal for one person but apparently subo...
The liver is one of the most sexually dimorphic organs. The hepatic metabolic pathways that are subject to sexual dimorphism include xenobiotic, amino acid and lipid metabolism. Non-alcoholic fatty liver disease and hepatocellular carcinoma are among diseases with sex-dependent prevalence, progression and outcome. Although male and female livers differ in their abilities to metabolize foreign compounds, including drugs, sex-de...
The Brazilian Cerrado is becoming hotter and drierNARA Subscribed
The Brazilian Cerrado is a global biodiversity hotspot with notoriously high rates of native vegetation suppression and wildfires over the past three decades. As a result, climate change can already be detected at both local and regional scales. In this study, we used three different approaches based on independent datasets to investigate possible changes in the daytime and nighttime temperature and air humidity between the pe...
Subcellular spatio-temporal intravital kinetics of aflatoxin B1 and ochratoxin A in liver and kidneyNARA Subscribed
Local accumulation of xenobiotics in human and animal tissues may cause adverse effects. Large differences in their concentrations may exist between individual cell types, often due to the expression of specific uptake and export carriers. Here we established a two-photon microscopy-based technique for spatio-temporal detection of the distribution of mycotoxins in intact kidneys and livers of anesthetized mice with subcellular...
Beyond nitrogen: phosphorus – estimating the minimum niche dimensionality for resource competition between phytoplanktonNARA Subscribed
The niche dimensionality required for coexistence is often discussed in terms of the number of limiting resources. N and P limitation are benchmarks for studying phytoplankton interactions. However, it is generally agreed that limitation by small numbers of resources cannot explain the high phytoplankton diversity observed in nature. Here, we parameterised resource competition models using experimental data for six phytoplankt...
Cover ImageNARA Subscribed
NEOTROPICAL ALIEN MAMMALS: a data set of occurrence and abundance of alien mammals in the NeotropicsNARA Subscribed
Biological invasion is one of the main threats to native biodiversity. For a species to become invasive, it must be voluntarily or involuntarily introduced by humans into a nonnative habitat. Mammals were among first taxa to be introduced worldwide for game, meat, and labor, yet the number of species introduced in the Neotropics remains unknown. In this data set, we make available occurrence and abundance data on mammal specie...
An andesitic sill complex in the Southern Permian Basin: volcanogenetic model and stratigraphic implicationsNARA Subscribed
Subvolcanic intrusions are highly variable in shape and structure, and occur in nearly all parts of the upper crust, as a result of extensive volcanic activity. Processes of subvolcanics interacting with the host rock are insufficiently understood, as they are rarely exposed. In the southernmost part of the Flechtingen-Altmark Subprovince, (sub)volcanic rocks of the Flechtingen Volcanic Complex (FVC) are exposed in several qua...
In 2019, the EPMA celebrated its 10th anniversary at the 5th World Congress in Pilsen, Czech Republic. The history of the International Professional Network dedicated to Predictive, Preventive and Personalised Medicine (PPPM / 3PM) is rich in achievements. Facing the coronavirus COVID-19 pandemic it is getting evident globally that the predictive approach, targeted prevention and personalisation of medical services is the opti...
Understanding the links between intraspecific trait variability and environmental gradients is an important step toward unravelling the mechanisms that link species performance to environmental variation. Here, we performed a comparative, experimental study to investigate variability of cellular traits in three prokaryotic and three eukaryotic freshwater phytoplankton species along gradients of temperature and nitrogen:phospho...
NEOTROPICAL XENARTHRANS: a data set of occurrence of xenarthran species in the NeotropicsNARA Subscribed
Xenarthrans—anteaters, sloths, and armadillos—have essential functions for ecosystem maintenance, such as insect control and nutrient cycling, playing key roles as ecosystem engineers. Because of habitat loss and fragmentation, hunting pressure, and conflicts with domestic dogs, these species have been threatened locally, regionally, or even across their full distribution ranges. The Neotropics harbor 21 species of armadillos,...