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Voxel-wise insights into early Alzheimer’s disease pathology progression: the association with APOE and memory declineNARA Subscribed
Longitudinal investigation of the Apolipoprotein E (APOE) genotype’s impact on Alzheimer’s disease (AD) biomarker progression, focusing on amyloid beta (Aβ) accumulation and gray matter (GM) atrophy, integrating cognitive decline and baseline levels. Longitudinal florbetapir-PET and T1-weighted MRI data from 100 cognitively normal (CN) and mild cognitive impaired (MCI) participants both with considerable global Aβ accumulation...
The fungal predominance in stem collar necroses of Fraxinus excelsior: a study on Hymenoscyphus fraxineus multilocus genotypesNARA Subscribed
Over the past decades, European ash trees in Germany have been affected by ash dieback, reducing their vigour and mechanical resistance. Those trees that also have stem collar necroses and the resulting stem rot are particularly affected. In this study, multilocus genotypes (MLGs) of Hymenoscyphus fraxineus and their interactions with other fungi from stem collar necroses were analysed. Ten ash trees from three different adjac...
Ash dieback assessments on intensive monitoring plots in Germany: influence of stand, site and time on disease progressionNARA Subscribed
Since 2002, ash dieback caused by the invasive fungus Hymenoscyphus fraxineus has been observed in Germany. The pathogen and its associated symptoms have fatal consequences for the vitality and survival of European ash ( Fraxinus excelsior L.), an economically and ecologically important tree species. This study analyses the ash monitoring results of eleven intensive monitoring plots of the FraxForFuture research network distri...
Cryptostroma corticale and fungal endophytes associated with Fraxinus excelsior affected by ash diebackNARA Subscribed
While assessing the filamentous fungi associated with woody tissues of stem collar rots, necroses, and lesions of European ash trees ( Fraxinus excelsior ) presenting symptoms of ash dieback in Germany, Cryptostroma corticale was recovered from three different ash trees. These isolated strains were the first report of C. corticale on ash and the first proof of an association of this plant pathogen with woody tissues of other t...
Marine Bacteroidetes that degrade polysaccharides contribute to carbon cycling in the ocean. Organic matter, including glycans from terrestrial plants, might enter the oceans through rivers. Whether marine bacteria degrade structurally related glycans from diverse sources including terrestrial plants and marine algae was previously unknown. We show that the marine bacterium Flavimarina sp. Hel_I_48 encodes two polysaccharide u...
Fungi associated with stem collar necroses of Fraxinus excelsior affected by ash diebackNARA Subscribed
In recent decades the vitality and physical stability of European ash trees in Germany have been reduced by European ash dieback, especially when associated with stem collar necroses and rots. This study was carried out to investigate the composition of the fungal communities associated with stem collar necroses. Filamentous fungi were isolated from 58 ash trees out of nine forest stands in northern, eastern, and central Germa...
FraxForFuture—research on European ash dieback in GermanyNARA Subscribed
European ash dieback caused by the alien, invasive ascomycete species Hymenoscyphus fraxineus currently represents, along with its side effects, the greatest threat to common ash ( Fraxinus excelsior ) trees in Europe. The disease is widely distributed in Germany and present in all regions where common ash is growing. In order to study European ash dieback in Germany and to develop management strategies to conserve common ash...
Multiple system atrophy (MSA) is a fatal neurodegenerative disease of unknown etiology characterized by widespread aggregation of the protein alpha-synuclein in neurons and glia. Its orphan status, biological relationship to Parkinson’s disease (PD), and rapid progression have sparked interest in drug development. One significant obstacle to therapeutics is disease heterogeneity. Here, we share our process of developing a clin...
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