The secreted peptide adropin is highly expressed in human brain tissues and correlates with RNA and proteomic risk indicators for dementia. Here we report that plasma adropin concentrations predict risk for cognitive decline in the Multidomain Alzheimer Preventive Trial (ClinicalTrials.gov Identifier, NCT00672685; mean age 75.8y, SD = 4.5 years, 60.2% female, n = 452). Cognitive ability was evaluated using a composite cognitiv...

Since 2010, considerable efforts have been undertaken to monitor the environmental status of European marine waters and ensuring the development of methodological standards for the evaluation of this status. However, the current routine biomonitoring implicates time‐consuming and costly manual sorting and morphological identification of benthic macrofauna. Environmental DNA (eDNA) metabarcoding represents an alternative to the...

This paper studies the behaviour of a quayside floater oscillating in front of a vertical dike. In order to study the floater motion and the impact of the dike on the floater, a linear analytical model based on 2D potential flow theory in intermediate water depth conditions and a numerical model resolving 2D Navier–Stokes equations are developed. Physical tests performed for different floater dimensions in a wave tank are used...

Studying evolutionary mechanisms in natural populations often requires testing multifactorial scenarios of causality involving direct and indirect relationships among individual and environmental variables. It is also essential to account for the imperfect detection of individuals to provide unbiased demographic parameter estimates. To cope with these issues, we developed a new approach combining structural equation models wit...

In some hole nesting passerine species, long‐term monitoring data are available for several geographically independent populations. Climate forcing can then be documented and predictions made on the scale of distribution ranges. Several demographic studies of Paridae report dramatic impacts of wintertime climatic factors. However, these studies were undertaken in populations located in the northern parts of the species' ranges...