Background The healing process after a myocardial infarction (MI) in humans involves complex events that replace damaged tissue with a fibrotic scar. The affected cardiac tissue may lose its function permanently. In contrast, zebrafish display a remarkable capacity for scar-free heart regeneration. Previous studies have revealed that syndecan-4 (SDC4) regulates inflammatory response and fibroblast activity following cardiac in...

Key message A practical approach is developed to determine a cost-effective optimal training set for selective phenotyping in a genomic prediction study. An R function is provided to facilitate the application of the approach. Abstract Genomic prediction (GP) is a statistical method used to select quantitative traits in animal or plant breeding. For this purpose, a statistical prediction model is first built that uses phenotyp...

Purpose Currently, diabetes and the consequent DN are considered a major public health issue. However, the mechanism of DN and its treatment require further clarification. This study proposed noninvasive T1-weighted (T1W) and T2-weighted (T2W) MRI protocols for the longitudinal assessment of kidney disease progression after DN induction in Sprague Dawley (SD) rats. Methods The changes in MRI image indices over time between con...