In the process of offshore natural gas extraction, natural gas hydrates tend to form within the wellbore. This secondary hydrate formation can potentially cause severe blockages. Current prediction methods primarily rely on temperature–pressure curves, which often overlook the critical effects of high-velocity fluid flow, particularly the impact and drag forces acting on the hydrates. To address this limitation, this study pro...

Circadian sensitivity significantly influences the severity of noise-induced hearing loss (NIHL), but the underlying mechanisms remain unclear. Here, we applied single-cell RNA sequencing to 97,043 cochlear cells, identifying macrophages as the primary immune responders to acoustic trauma, with a notable increase in their proportion in the cochlea. Immunofluorescence confirmed significant recruitment and activation of cochlear...