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Voxel-wise insights into early Alzheimer’s disease pathology progression: the association with APOE and memory declineNARA Subscribed
Longitudinal investigation of the Apolipoprotein E (APOE) genotype’s impact on Alzheimer’s disease (AD) biomarker progression, focusing on amyloid beta (Aβ) accumulation and gray matter (GM) atrophy, integrating cognitive decline and baseline levels. Longitudinal florbetapir-PET and T1-weighted MRI data from 100 cognitively normal (CN) and mild cognitive impaired (MCI) participants both with considerable global Aβ accumulation...
Complementary value of molecular, phenotypic, and functional aging biomarkers in dementia predictionNARA Subscribed
DNA methylation age (MA), brain age (BA), and frailty index (FI) are putative aging biomarkers linked to dementia risk. We investigated their relationship and combined potential for prediction of cognitive impairment and future dementia risk using the ADNI database. Of several MA algorithms, DunedinPACE and GrimAge2, associated with memory, were combined in a composite MA alongside BA and a data-driven FI in predictive analyse...
Guiding principles for rewildingNARA Subscribed
There has been much recent interest in the concept of rewilding as a tool for nature conservation, but also confusion over the idea, which has limited its utility. We developed a unifying definition and 10 guiding principles for rewilding through a survey of 59 rewilding experts, a summary of key organizations’ rewilding visions, and workshops involving over 100 participants from around the world. The guiding principles convey...
Patterns of ecosystem development in glacial foreland chronosequences: a comparative analysis of Chile and New ZealandNARA Subscribed
After catastrophic disturbances, depleted substrates are readily colonised by organisms that capture nitrogen from the atmosphere and extract phosphorus from minerals. Our main objective was to compare the pattern of ecosystem development following deglaciation in Chile and New Zealand. Results show a similar pattern of C and N accumulation and decline in soil chronosequences, similar decline in biological nitrogen fixation (B...
Location, location, location: priority effects in wood decay communities may vary between sitesNARA Subscribed
Summary Priority effects are known to have a major influence on fungal community development in decomposing wood, but it has not yet been established whether these effects are consistent between different geographical locations. Here, beech ( F agus sylvatica ) wood disks that had been pre‐colonized with three wood decay basidiomycetes were placed in seven woodland sites with similar characteristics for 12–24 months, and the s...
Future human well‐being under climate change depends on the ongoing delivery of food, fibre and wood from the land‐based primary sector. The ability to deliver these provisioning services depends on soil‐based ecosystem services (e.g. carbon, nutrient and water cycling and storage), yet we lack an in‐depth understanding of the likely response of soil‐based ecosystem services to climate change. We review the current knowledge o...
Large losses of soil C and N from soil profiles under pasture in New Zealand during the past 20 yearsNARA Subscribed
The conversion of two‐thirds of New Zealand's native forests and grasslands to agriculture has followed trends in other developed nations, except that pastoral grazing rather than cropping dominates agriculture. The initial conversion of land to pasture decreased soil acidity and elevated N and P stocks, but caused little change in soil organic C stocks. However, less is known about C and nutrient stock changes during the last...
Humans in the Hoxnian: habitat, context and fire use at Beeches Pit, West Stow, Suffolk, UKNARA Subscribed
A Lower Palaeolithic industry at Beeches Pit, West Stow, Suffolk, occurs within an interglacial sequence that immediately overlies glacial deposits, referable to the Anglian Lowestoft Formation. There is strong biostratigraphical evidence from both vertebrates and molluscs that the interglacial represented is the Hoxnian (MIS 11). This conclusion is supported by uranium series dates from carbonate nodules (>400 kyr), TL dates...
Archaeological excavations at Southfleet Road, Ebbsfleet, Kent, have revealed a complex sequence of fossiliferous Middle Pleistocene sediments containing lithic artefacts. An incomplete skeleton of straight‐tusked elephant Palaeoloxodon antiquus was found in lacustrine sediments in close association with a cluster of mint condition cores, flakes and notched flake‐tools, some with evidence of use‐damage. These finds appear to r...
s 60th annual PAA meeting (Part II)NARA Subscribed
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