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METTL3 and METTL14, key components of the m 6 A writer complex, are frequently overexpressed in various malignancies, including acute myeloid leukemia (AML), where aberrant methylation has been linked to the upregulation of oncogenic transcription. Therefore, targeting the METTL3/METTL14 complex represents a potential therapeutic approach for AML. Although several METTL3 inhibitors have been discovered, their SAM-competitive m...
Xanthium cockle burrs are invasive weeds in many countries, affecting local ecosystems and agriculture. All Xanthium in Australia are naturalised weeds from multiple overseas sources, but their taxonomic identities are contentious. In particular, species identities of four burr varieties or “complexes” under Xanthium section Xanthium in Australia are unclear. These complexes, commonly referred to as “Noogoora”, “Californian”,...