Genetic and other predisposing factors can influence the progression from initiation of drug intake to compulsive substance use through distinct biobehavioral processes. Operant cocaine self-administration studies in laboratory mice offer a powerful method to dissect the biology of this progression from initiation, dose-response, extinction, and cued reinstatement in a controlled, tractable system. However, many such studies e...

The McDermitt caldera (Oregon–Nevada, USA) hosts the largest volcano-sedimentary (VS) Li resource globally. This study presents an integrated geological, mineralogical, and isotopic investigation of the McDermitt deposit in Oregon, with the aim of constraining the processes responsible for Li enrichment in clay-type VS Li mineralization. Our study reveals that Li mineralization occurs in stratiform lacustrine units composed of...

Gene‒gene interactions play pivotal roles in disease pathogenesis and are fundamental in the development of targeted therapeutics, particularly through the elucidation of oncogenic gene drivers in cancer. The systematic analysis of pathways and gene interactions is critical in the drug discovery process for various cancer subtypes. SPAG5, known for its role in spindle formation during cell division, has been identified as an o...

A species' success during the invasion of new areas hinges on an interplay between the demographic processes common to invasions and the specific ecological context of the novel environment. Evolutionary genetic studies of invasive species can investigate how genetic bottlenecks and ecological conditions shape genetic variation in invasions, and our study pairs two invasive populations that are hypothesized to be from the same...

To recover species at risk, it is necessary to identify habitat critical to their recovery. Challenges for species with large ranges (thousands of square kilometres) include delineating management unit boundaries within which habitat use differs from other units, along with assessing any differences among units in amounts of and threats to habitat over time. We developed a reproducible framework to support identification of cr...

Existing phenotype ontologies were originally developed to represent phenotypes that manifest as a character state in relation to a wild-type or other reference. However, these do not include the phenotypic trait or attribute categories required for the annotation of genome-wide association studies (GWAS), Quantitative Trait Loci (QTL) mappings or any population-focussed measurable trait data. The integration of trait and biol...

Batoid fishes are among the most endangered marine vertebrates, yet conservation efforts have been confounded by incomplete taxonomy. Evidence suggest that the critically endangered ‘common skate’ actually represents two species: the flapper skate ( Dipturus intermedius ) and the blue skate ( Dipturus batis ). However, knowledge of the geographic range of these two nominal species is limited. Here, DNA sequencing is used to di...

Despite the ecological significance of the mutualistic relationship between Symbiodiniaceae and reef‐building corals, the molecular interactions during establishment of this relationship are not well understood. This is particularly true of the transcriptional changes that occur in the symbiont. In the current study, a dual RNA‐sequencing approach was used to better understand transcriptional changes on both sides of the coral...

The concept of “blue growth,” which aims to promote the growth of ocean economies while holistically managing marine socioecological systems, is emerging within national and international marine policy. The concept is often promoted as being novel; however, we show that historical analogies exist that can provide insights for contemporary planning and implementation of blue growth. Using a case‐study approach based on expert k...