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Development of RS1-specific ACMG/AMP variant classification criteria with pilot variant curationNARA Subscribed
Gene-based therapies are being developed for retinal diseases, including RS1- related X-linked retinoschisis. Therefore it is essential to determine which variants are pathogenic and which are benign when enrolling patients. The Clinical Genome Resource (ClinGen) X-Linked Inherited Retinal Diseases (XLRD) Variant Curation Expert Panel (VCEP) brings together clinician scientists, molecular biologists, and geneticists to apply t...
A Framework to Investigate the Effects of Observation Error on Neural Network Predictions of Fish AgeNARA Subscribed
Technological innovations for predicting fish age represent a paradigm shift from conventional age estimation methods used in fisheries science. Recently developed secondary methods rely on models trained on conventional age estimates, derived from subjective interpretation of growth patterns and a biological property of the fish to predict age. Hence, quantifying the error that propagates from these models and the conventiona...
SNAPSHOT USA 2024: Year 6 of the Coordinated National Camera Trap Survey of the United StatesNARA Subscribed
Motivation SNAPSHOT USA is an annual, multi‐contributor camera trap survey of mammals across the United States. The growing SNAPSHOT USA dataset is intended for tracking the spatial and temporal responses of mammal populations to changes in land use, land cover and climate. These data will be useful for exploring the drivers of spatial and temporal changes in relative abundance and distribution, as well as the impacts of speci...
Marine megafauna species are affected by a wide range of anthropogenic threats. To evaluate the risk of such threats, species’ vulnerability to each threat must first be determined. We build on the existing threats classification scheme and ranking system of the International Union for Conservation of Nature (IUCN) Red List of Threatened Species by assessing the vulnerability of 256 marine megafauna species to 23 at‐sea threat...
A method to identify positive tipping points to accelerate low-carbon transitions and actions to trigger themNARA Subscribed
Meeting the Paris Agreement to limit global warming to “well below 2 °C” requires a radical acceleration of action, as the global economy is decarbonising at least five times too slowly. Tipping points, where low-carbon transitions become self-propelling, could be key to achieving the necessary acceleration. We deem these normatively ‘positive’, because they can limit considerable, inequitable harms from global warming and hel...
Environmental and Geographic Conditions on the Breeding Grounds Drive Bergmannian Clines in NightjarsNARA Subscribed
Aim To evaluate (1) whether three migratory nightjar species (Family Caprimulgidae) adhere to Bergmann's rule, (2) whether environmental factors on the breeding or wintering grounds determine body size, and (3) which mechanistic hypotheses best explain Bergmannian patterns in body size. Location North and South America; Europe and Africa. Taxon Eastern whip‐poor‐will ( Antrostomus vociferus ), Common nighthawk ( Chordeiles min...
Elevated Contact Stresses Compromise Activity-Mediated Cartilage Rehydration but not LubricationNARA Subscribed
Purpose Understanding how obesity—a key risk factor for osteoarthritis—effects articular cartilage function is critical to understand OA pathoetiology. Cartilage, a biphasic material, supports vanishingly low friction coefficients in vivo, but is tribomechanically compromised by load-induced interstitial pressure/lubrication loss. To maintain tribomechanical function, cartilage must recover fluid lost to habitual/average conta...
SNAPSHOT USA 2019–2023: The First Five Years of Data From a Coordinated Camera Trap Survey of the United StatesNARA Subscribed
Motivation SNAPSHOT USA is an annual, multicontributor camera trap survey of mammals across the United States. The growing SNAPSHOT USA dataset is intended for tracking the spatial and temporal responses of mammal populations to changes in land use, land cover and climate. These data will be useful for exploring the drivers of spatial and temporal changes in relative abundance and distribution, as well as the impacts of specie...
A Functional Response in Resource Selection Links Multiscale Responses of a Large Carnivore to Human Mortality RiskNARA Subscribed
Theory suggests that animals make hierarchical, multiscale resource selection decisions to address the hierarchy of factors limiting their fitness. Ecologists have developed tools to link population‐level resource selection across scales; yet, theoretical expectations about the relationship between coarse‐ and fine‐scale selection decisions at the individual level remain elusive despite their importance to fitness. With GPS‐te...
Animals within social groups respond to costs and benefits of sociality by adjusting the proportion of time they spend in close proximity to other individuals in the group (cohesion). Variation in cohesion between individuals, in turn, shapes important group‐level processes such as subgroup formation and fission–fusion dynamics. Although critical to animal sociality, a comprehensive understanding of the factors influencing coh...
Purpose The objective of this study was to investigate whether different dispensing processes can alter the physicochemical and structural (Q3) attributes of a topical cream product, and potentially alter its performance. Methods Acyclovir cream, 5% (Zovirax®) is sold in the UK and other countries in a tube and a pump packaging configurations. The structural attributes of the cream dispensed from each packaging configuration w...
Forests around the world are experiencing changes due to climate variability and human land use. How these changes interact and influence the vulnerability of forests are not well understood. In the eastern United States, well‐documented anthropogenic disturbances and land‐use decisions, such as logging and fire suppression, have influenced forest species assemblages, leading to a demographic shift from forests dominated by xe...