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Endoplasmic reticulum aminopeptidases (ERAP) facilitate antigen presentation. Variation in ERAP1 and ERAP2 genes underwent selection during the Black Death and impact autoimmune disease susceptibility. We assess the burden of functionally impactful variants present in ERAP1 and ERAP2 in 2 cohorts of patients diagnosed with inflammatory bowel disease (IBD; Crohn’s disease (CD) or ulcerative colitis (UC)). We analysed the Southa...
Purpose Residential segregation is recognized as an upstream driver of poor health, yet few studies have evaluated its impact on breast cancer incidence at a local level. We examined associations of neighborhood residential segregation with breast cancer (BC) incidence in the Multiethnic Cohort Study (MEC). Methods Measures of Index of Concentration at the Extremes were developed to assess residential segregation by income, ed...
Precision measurement of the Ds*+-Ds+ meson mass differenceNARA Subscribed