R. Clements results 129
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Monitoring of Colorectal Cancer Screening Adherence Among African American Patients of North Florida Community Health CentersNARA Subscribed
In the United States, colorectal cancer (CRC) mortality rates are higher in African Americans compared to non-Hispanic whites, partly due to advanced stage cancer diagnosis. Timely CRC screening helps to increase CRC early detection and survival in this population. The objective of this monitoring study was to survey African American patients of Community Health Centers (CHC) in north Florida and to monitor CRC screening adher...
Fentanyl decreases arterial blood oxygen saturation more than furanylfentanyl in mice due to increased apneaNARA Subscribed
Rationale Fatal opioid overdoses involving synthetic opioids have increased >10-fold over the past 8 years. Fentanyl, a potent synthetic opioid acting at the mu-opioid receptor (MOR), has largely replaced heroin as the predominant illicit opioid available. Various analogs have been synthesized from the fentanyl scaffold, including 2-furanylfentanyl, one of the most trafficked analogs from 2019 to 2024. Despite its prevalence,...
Microcosms, or miniature experimental systems, have been used to develop models and theories in ecology. However, their contribution to conservation science is unclear. We explored the application, design, and impact of microcosms in conservation science from 469 systematically identified articles published from 1986 to 2023. We used generalized linear modeling to compare cumulative citations over time for each microcosm artic...
Thierry B.R. Chopin (1959–2024) – Innovator of Modern IMTANARA Subscribed
Co‐Extinctions and Co‐Compensatory Species Responses to Climate Change Moderate Ecosystem FuturesNARA Subscribed
Consensus has been reached that the sequential loss of biodiversity leads to a non‐linear and accelerating decline in ecosystem properties. The form of this relationship, however, is based on theory and empirically derived observations that do not include species co‐extinctions. Here, we use data from marine benthic invertebrate communities to parameterise trait‐based extinction models that adjust the probability of species ex...
Pharmacokinetics and Pharmacodynamics of Nomlabofusp in Non-clinical Studies of Friedreich’s AtaxiaNARA Subscribed
Nomlabofusp is a cell penetrant peptide-based recombinant fusion protein designed to enter cells and deliver human frataxin into the mitochondria of adults and children with Friedreich’s ataxia. In this article we present non-clinical studies evaluating the pharmacology of nomlabofusp, including in a murine striated muscle tissue frataxin knockout model of Friedreich’s ataxia. We demonstrate that subcutaneous administration of...
Operational forecasts rely on accurate and timely observations and it is important that the ocean forecasting community demonstrates the impact of those observations to the observing community and its funders while providing feedback on requirements for the design of the ocean observing system. One way in which impact of new observations can be assessed is through Observing System Simulation Experiments (OSSEs). Various satell...