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The in vitro alkaline comet assay with liver models as a complementary tool for genotoxicity assessment of N-nitrosaminesNARA Subscribed
N -nitrosamine (NA) impurities in pharmaceuticals represent “cohort of concern” compounds under ICH M7(R2), due to their mutagenic/carcinogenic potential, involving cytochrome P450 (CYP)-mediated metabolic activation. Increasing interest in mammalian cell-based genotoxicity/mutagenicity assays prompted our assessment of the in vitro alkaline comet assay regarding its predictive power for NAs. Here, precision-cut liver slices (...
Environmental warming increases the importance of high‐turnover energy channels in stream food websNARA Subscribed
Warming temperatures are altering communities and trophic networks across Earth's ecosystems. While the overall influence of warming on food webs is often context‐dependent, increasing temperatures are predicted to change communities in two fundamental ways: (1) by reducing average body size and (2) by increasing individual metabolic rates. These warming‐induced changes have the potential to influence the distribution of food...
Comparing environmental impacts of deep‐seabed and land‐based mining: A defensible frameworkNARA Subscribed
The crises of climate change and biodiversity loss are interlinked and must be addressed jointly. A proposed solution for reducing reliance on fossil fuels, and thus mitigating climate change, is the transition from conventional combustion‐engine to electric vehicles. This transition currently requires additional mineral resources, such as nickel and cobalt used in car batteries, presently obtained from land‐based mines. Most...
Uncovering relationships between landscape diversity and species interactions is crucial for predicting how ongoing land‐use change and homogenization will impact the stability and persistence of communities. However, such connections have rarely been quantified in nature. We coupled high‐resolution river sonar imaging with annualized energetic food webs to quantify relationships among habitat diversity, energy flux, and troph...
Sustainable agricultural development not only addresses global food insecurity but may also alleviate poverty by enriching the lives of millions of smallholder farmers. Improving the sustainability and profitability of agriculture where smallholders are dominant creates profound impacts because small landholding farmers produce approximately 70–80% of the global food. The need for a thorough understanding of the factors affect...
183 Effects of prolonged hay net feeding on equine behaviorNARA Subscribed
Winter conditions structure extratropical patterns of species richness of amphibians, birds and mammals globallyNARA Subscribed
Aim The aim was to derive global indices of winter conditions and examine their relationships with species richness patterns outside of the tropics. Location All extratropical areas (>25° N and 25° S latitudes), excluding islands. Time period 2000–2018. Major taxa studied Amphibians, birds and mammals. Methods We mapped three global indices of winter conditions [number of days of frozen ground (length of frozen ground winter);...
Prolonging survival in good health is a fundamental societal goal. However, the leading determinants of disability-free survival in healthy older people have not been well established. Data from ASPREE, a bi-national placebo-controlled trial of aspirin with 4.7 years median follow-up, was analysed. At enrolment, participants were healthy and without prior cardiovascular events, dementia or persistent physical disability. Disab...
Effective data management plays a key role in oceanographic research as cruise-based data, collected from different laboratories and expeditions, are commonly compiled to investigate regional to global oceanographic processes. Here we describe new and updated best practice data standards for discrete chemical oceanographic observations, specifically those dealing with column header abbreviations, quality control flags, missing...
The early marine distribution of Atlantic salmon in the North‐east Atlantic: A genetically informed stock‐specific synthesisNARA Subscribed
The survival of Atlantic salmon ( Salmo salar) , an increasingly rare anadromous species, has declined dramatically during its marine phase, with disproportionate impacts on the poorly understood early post‐smolt period. Logistical constraints on collecting oceanic data to inform this issue pose a formidable obstacle. To advance understanding of post‐smolt distributional ecology in the North‐east Atlantic, a comprehensive anal...
Body size and digestive system shape resource selection by ungulates: A cross‐taxa test of the forage maturation hypothesisNARA Subscribed
The forage maturation hypothesis (FMH) states that energy intake for ungulates is maximised when forage biomass is at intermediate levels. Nevertheless, metabolic allometry and different digestive systems suggest that resource selection should vary across ungulate species. By combining GPS relocations with remotely sensed data on forage characteristics and surface water, we quantified the effect of body size and digestive syst...
R esource supply governs the apparent temperature dependence of animal production in stream ecosystemsNARA Subscribed
Rising global temperatures are changing how energy and materials move through ecosystems, with potential consequences for the role of animals in these processes. We tested a central prediction of the metabolic scaling framework—the temperature independence of animal community production—using a series of geothermally heated streams and a comprehensive empirical analysis. We show that the apparent temperature sensitivity of ani...