The autosomal dominant multisystemic Alagille Syndrome (ALGS) is an important cause of pediatric cholestasis. ALGS is associated with pathogenic variants in JAGGED1 (JAG1) or NOTCH2, ligand and receptor components of the Notch-signaling pathway, respectively. The detected missense variants are commonly classified as variants of uncertain significance, hindering ALGS diagnosis. To overcome this issue, we have developed a CRISPR...

As thermal stress intensifies under global climate change, ecosystems worldwide are undergoing profound transformations that disrupt biological processes, species distributions and biodiversity, with coastal marine systems particularly vulnerable. Organisms have evolved behavioural, physiological and morphological strategies to cope with extreme conditions, while species interactions, especially symbioses, can further shape re...

Water banking offers a transformative solution to freshwater scarcity, but stakeholder involvement is essential for success. Responsible Innovation (RI) and Value Sensitive Design (VSD) include stakeholders in design but both exhibit methodological flaws. This study addressed these limitations by performing an exploratory synthesis of the two approaches within an empirical case in the Dutch Southwestern Delta. First, a systema...

Situated in the Cabo Verde Archipelago, Fogo is among the most active oceanic volcanoes in the Atlantic, hosting frequent eruptions some of which were highly explosive and at least one gravitational flank collapse in the last 100 kyr. This study presents new volcanic glass shard geochemical data with high spatial distribution from 54 sites comprising samples from both pre- and post-collapse times. The analyzed glasses comprise...

Accurate inference of sexual maturity is fundamental to interpreting marine mammal life histories and population structure. Using Bayesian logistic regression models with a hierarchical ordinal (HOF‐style) parameterisation and canonical analysis of principal coordinates (CAP), we evaluate skeletal metrics in the pectoral flippers of common dolphin ( Delphinus delphis ) as indicators of attainment of sexual maturity. HOF models...

Key message This first account of Oregon ash somatic embryogenesis identifies unique auxin and abscisic acid responses distinct from green and white ash, advancing clonal propagation techniques for reforestation. Abstract Oregon ash ( Fraxinus latifolia ), the only ash species native to the Pacific Northwest, is vulnerable to the invasive beetle, emerald ash borer (EAB; Agrilus planipennis ). EAB was first detected in North Am...