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Stomatal Decoupling From Photosynthesis Under High Temperatures Is Consistent With Stomatal OptimisationNARA Subscribed
Stomatal pores on plant leaves regulate the gain of carbon through photosynthesis and the loss of water through transpiration. Through their responses to environmental conditions, stomata can constrain plant productivity and transpiration fluxes, exerting a strong control on climate feedbacks over land. Although mechanistic modelling of stomata remains a challenge, semi‐empirical and optimisation models have been successfully...
Precision measurement of the Ds*+-Ds+ meson mass differenceNARA Subscribed
Discovery of a Potent Small Molecule Antagonist of GRPR for the Treatment of PruritusNARA Subscribed
Persistent pruritus (itch) affects the quality of life, and many itch syndromes remain untreatable. Previously, we identified the gastrin-releasing peptide receptor (GRPR) playing a critical role in mediating histamine-independent itch signaling. In this study, we aimed to identify small-molecule GRPR antagonists to treat histamine-independent itch. Starting with the known small-molecule GRPR antagonist PD 176,252, we conducte...
Personalizing treatment of pancreatitis-associated chronic pain: the need for an integrated omics approachNARA Subscribed
Background Chronic pancreatitis (CP) is a progressive inflammatory disorder characterized by debilitating chronic pain and substantial healthcare burden. Pain mechanisms in CP are heterogeneous and incompletely integrated into clinical decision-making. This narrative review synthesizes data from human CP cohorts and complementary experimental models to summarize inflammatory, neuropathic, and metabolic drivers of pancreatitis-...
Anthropogenic phosphorus (P) inputs are rapidly altering terrestrial P cycling through plant – soil – microbial interactions; however, global patterns and underlying mechanisms driving these changes remain poorly understood. By performing a global meta‐analysis of 1315 observations from 176 studies across diverse natural terrestrial ecosystems, we found that P addition increased P concentrations in foliage, stems, roots, and l...
South America contains some of the world’s most ecologically and hydrologically diverse freshwater systems, which are increasingly vulnerable to climate change and human pressures. Despite their importance, the diurnal and interannual variability of lake surface water temperature (LSWT) across the continent remains poorly understood. In this study, we analyze thermal patterns in 2,406 South American lakes, spanning both histor...