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Background Growth differentiation factor 15 (GDF15) is a biomarker for cardiovascular diseases, and its circulating levels are altered in preeclampsia (PE), which shares mechanisms with cardiovascular diseases. Several SNPs in the GDF15 locus were associated with GDF15 levels, including the GWAS lead SNP rs888663. However, no previous study had performed a functional characterization of rs888663 nor had tested the hypothesis t...
Angus cattle, originally from Scotland, have been selectively bred for over 400 years, making them one of the most prominent beef breeds globally. Known for their adaptability, natural polled traits, and high-quality beef, Angus cattle have been intensively selected for growth, body size, and feed efficiency. This study investigates the genetic diversity, selection history, and key genomic regions across five Angus populations...
Fine-tuning alkyl chain length in copper(II) complexes: effects on DNA binding and catalytic cleavageNARA Subscribed
Metal complexes are well known for their DNA cleavage activity. Copper is a metal that stands out for this purpose because it is able to perform cleavage through oxidative mechanisms using the Haber–Weiss cycle. We report two unprecedented copper(II) complexes ( 2 and 3 ) with long-chain ligands and compare the results with those of a previously reported complex ( 1 ), which we use as a reference in our studies. They were all...
Species of Micropleura Linstow, 1906 (Dracunculoidea: Nematoda) are common parasites of crocodilians worldwide. Studies related to this genus remain scarce, particularly regarding genetic characterizations, due to the difficulty in obtaining the parasite specimens. Although the morphology of M . vazi Travassos, 1933, a parasite of Caiman spp. in the Neotropics, has been previously evaluated, some morphological inconsistencies...
This study reports the optimization of a cost‐effective one‐step PCR assay for the detection of White Spot Syndrome Virus (WSSV) in wild shrimp populations, providing an accessible alternative to expensive commercial nested PCR kits in Mozambique. Primer sets targeting VP19, VP24, VP26 and VP28 were evaluated, with the VP28_2 primer set demonstrating the highest sensitivity and no cross‐reactivity with Infectious Hypodermal an...
Population‐specific bycatch risks in two vulnerable anadromous clupeids: Insights from otolith microchemistryNARA Subscribed
Otolith microchemistry analysis revealed that bycatch of European shads, allis shad Alosa alosa and twaite shad Alosa fallax , in western Iberian commercial fisheries removes individuals from a wide array of natal origins, with the most abundant source rivers suffering the heaviest losses. Spatial variation in bycatch risk was evident: Specific marine areas exhibited high natal origin diversity, reflecting complex dispersal. A...