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In humans, testicular peritubular cells (TPCs) form a small compartment surrounding the seminiferous tubules and, as shown previously, undergo age-related changes. How they may contribute to the age-associated decline of testicular functions is not well known. Likewise, the mechanisms of testicular aging in humans are not well examined. This is in part due to the lack of appropriate cellular models. We aimed to establish an ag...
Ecosystem Metabolic Rates Estimated from Diel Oxygen Measurements in Two Subtropical EstuariesNARA Subscribed
Subtropical estuaries worldwide are facing increasing pressure from human population growth, development, and climate change. Carbon is a useful currency for understanding how estuaries respond to these pressures and yet relatively little is known about carbon cycling in subtropical estuaries. Here we compute gross primary production (GPP), ecosystem respiration (ER), and net ecosystem production (NEP) from the diurnal cycle i...
Climate change is a major threat to biodiversity, and migratory animals are particularly vulnerable, due partly to their reliance upon good resource availability across a network of sites at specific times. Migrants perform vital ecosystem functions, transferring significant resources across large spatial scales, but the impacts of climate change on the ability of individuals to complete these journeys are poorly studied. Coll...
Isolating the drivers of the species‐area relationship in experimental habitat islandsNARA Subscribed
Aim Considered one of ecology's laws, the species‐area relationship (SAR) is among the most intensively studied ecological phenomena, yet the mechanisms through which the SAR arises and under what circumstances remain poorly understood. Here, we experimentally test the effects of area alone in the absence of commonly invoked mechanistic drivers of the SAR in both sub‐tidal bay and inter‐tidal marsh habitats. Location Louisiana...
Near Eastern monumental buildings once hosted institutions with a variety of economic and environmental footprints. In this article examining a Middle Bronze Age II (seventeenth century BC) building complex at Zincirli, Turkey, we integrate bioarchaeological remains with ceramic and artifactual evidence to evaluate whether this building was a specialized node in a broader network and centralized economy. Combining seed/fruit/c...
Joint effects of climate, tree size, and year on annual tree growth derived from tree‐ring records of ten globally distributed forestsNARA Subscribed
Tree rings provide an invaluable long‐term record for understanding how climate and other drivers shape tree growth and forest productivity. However, conventional tree‐ring analysis methods were not designed to simultaneously test effects of climate, tree size, and other drivers on individual growth. This has limited the potential to test ecologically relevant hypotheses on tree growth sensitivity to environmental drivers and...
Rationale Risk factors for drug addiction include genetics, environment, and behavioral traits such as impulsivity and novelty preference (NP), which have been related to deficits in striatal dopamine (DA) D 2/3 -receptors (D 2/3 R) and heightened amphetamine (AMPH)-induced DA release. However, the influence of the early rearing environment on these behavioral and neurochemical variables is not clear. Objectives We investigate...
Hippocampal and Prefrontal Cortical Brain Tissue Levels of Irisin and GDF15 Receptor Subunits in ChildrenNARA Subscribed
Cold-stress hormones (CSHs) stimulate thermogenesis and have direct neuroprotective effects on the brain. The obligatory receptor components of two new CSHs (irisin and growth differentiation factor-15 [GDF15]) were recently discovered. Irisin binds integrin-αV/β5 heterodimers while GDF-15 binds to the orphan receptor glial cell-derived neurotrophic factor (GDNF) family receptor α-like (GFRAL). In addition, integrin-αV/β5 was...
The two fentanyl homologs cyclopropanoyl-1-benzyl-4´-fluoro-4-anilinopiperidine (4F-Cy-BAP) and furanoyl-1-benzyl-4-anilinopiperidine (Fu-BAP) have recently been seized as new psychoactive substances (NPS) on the drugs of abuse market. As their toxicokinetic and toxicodynamic characteristics are completely unknown, this study focused on elucidating their in vitro metabolic stability in pooled human liver S9 fraction (pHLS9), t...
Landscape corridors mitigate the negative effects of habitat fragmentation by increasing dispersal. Corridors also increase biodiversity in connected habitat fragments, suggestive of metacommunity dynamics. What is unknown in this case is the mechanisms through which metacommunity dynamics act. Working in a large‐scale fragmentation experiment, we tested the effect of corridors on the movement of prey species and subsequent ef...