R. Hutton results 27
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The lastreopsid ferns currently comprise four genera, with two of them, Lastreopsis and Parapolystichum , poorly delimited morphologically. Attribution of species to Lastreopsis or Parapolystichum has principally been by phylogenetic analysis of chloroplast DNA sequences. The last of the Australasian species of Lastreopsis to have its phylogenetic placement investigated is Lastreopsis nephrodioides , endemic to Lord Howe Islan...
Evaluation of physical and chemical modifications to drug reservoirs for stimuli-responsive microneedlesNARA Subscribed
Hydrogel-forming microneedle (MN) arrays are minimally-invasive devices that can penetrate the stratum corneum , the main barrier to topical drug application, without causing pain. However, drug delivery using hydrogel-forming MN arrays tends to be relatively slow compared to rapid drug delivery using conventional needles and syringes. Therefore, in this work, for the first time, different physical and chemical delivery enhanc...
Purpose Whilst significant progress has been made to defeat HIV infection, the efficacy of antiretroviral (ARV) therapy in the paediatric population is often hindered by poor adherence. Currently, two long-acting (LA) intramuscular injectable nanosuspensions of rilpivirine (RPV) and cabotegravir (CAB) are in clinical development for paediatric populations. However, administration requires access to healthcare resources, is pai...
Designing a unique feedback mechanism for hydrogel-forming microneedle array patches: a concept studyNARA Subscribed
Although microneedle array patch (MAP) technology is reaching ever closer to regulatory approval, it remains imperative that approaches to further improve patient acceptance are still explored. Addressing this perception, a water-filled reservoir was incorporated into a hydrogel-forming MAP system to provide a novel feedback mechanism. To confirm successful MAP skin insertion, the end user would both hear and feel the rupture...
Common, low-frequency, rare, and ultra-rare coding variants contribute to COVID-19 severityNARA Subscribed
The combined impact of common and rare exonic variants in COVID-19 host genetics is currently insufficiently understood. Here, common and rare variants from whole-exome sequencing data of about 4000 SARS-CoV-2-positive individuals were used to define an interpretable machine-learning model for predicting COVID-19 severity. First, variants were converted into separate sets of Boolean features, depending on the absence or the pr...
Wrestling with the complexity of evaluation for organizations at the boundary of science, policy, and practiceNARA Subscribed
Boundary organizations are situated between science, policy, and practice and have a goal of supporting communication and collaboration among these sectors. They have been promoted as a way to improve the effectiveness of conservation efforts by building stronger relationships between scientists, policy makers, industry, and practitioners (Cook et al. 2013). Although their promise has been discussed in theory, the work of and...
Islanders, commercial non‐indigenous fishers and P apua N ew G uinea fishers share the tropical rock lobster fishery, P anulirus ornatus ( F abricius) in T orres S trait. As the fishery is in the process of moving from input to output controls, a pre‐implementation understanding of indigenous fishers' perceptions of the potential impact of different quota management systems is gained. This study, based on workshops and intervi...
One Hundred Questions of Importance to the Conservation of Global Biological DiversityNARA Subscribed
We identified 100 scientific questions that, if answered, would have the greatest impact on conservation practice and policy. Representatives from 21 international organizations, regional sections and working groups of the Society for Conservation Biology, and 12 academics, from all continents except Antarctica, compiled 2291 questions of relevance to conservation of biological diversity worldwide. The questions were gathered...