Three new isatin–pyridine-2-oxime hybrids (AM01–03) were synthesized and experimentally evaluated as reactivators of acetylcholinesterase (AChE) inhibited by a surrogate of the nerve agent A-242, in comparison with their 4-oxime isomers previously reported by our research group. Furthermore, the interactions of these molecules within the AChE/A-242 complex were assessed through docking and molecular dynamics (MD) simulations....

Rapid urbanisation and population growth in Bangladesh have intensified ambient particulate matter (PM 2.5 and PM 10 ) pollution, posing critical threats to public health. This study assessed PM concentration in three major industrial cities, Dhaka, Narayanganj, and Gazipur. PM concentrations were measured using an Air Particle Counter and an optimised air-quality sensor. PM measurements were conducted at 138 sampling points a...

There is a ubiquitous co-occurrence of microplastics (MPs) and estrogenic endocrine disrupting chemicals (EEDCs) in aquatic environments. Their combined presence may induce sub-lethal stress in aquatic organisms, like molluscs, which may adapt to the stress through adjusting the lipidome. This study explored the individual and combined effects of polyethylene microplastics (PE-MPs) and a mixture of EEDCs at environmentally rea...