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Evaluation of the Anti-Inflammatory Effects of Novel Fatty Acid-Binding Protein 4 Inhibitors in MicrogliaNARA Subscribed
Fatty acid-binding protein 4 (FABP4) is a key lipid binding protein expressed in microglia, which has been demonstrated to play a critical role in microglial-mediated neuroinflammation, a component of many neurodegenerative diseases. Compounds able to inhibit the function of FABP4 have shown promise in reducing microglial-mediated neuroinflammation, however, their physicochemical properties would prevent their ability to be ea...
Ecohydrological Response of a Tropical Peatland to Rainfall Changes Driven by Intertropical Convergence Zone VariabilityNARA Subscribed
Aim Tropical peatlands are globally significant carbon stores, increasingly threatened by human activities and climate change. However, their ecohydrological responses to shifting water availability remain poorly understood. In this study, we investigate the connections between climate change, hydrology and vegetation dynamics in a coastal tropical peatland in Panama, aiming to understand the effects of future drying on peatla...
The biogeography and evolution of land ownershipNARA Subscribed
Aim Land ownership norms are well documented and play a central role in social–ecological systems. Yet only recently has the spatial and temporal distribution of land ownership been examined using biogeographical and evolutionary approaches. We incorporate biogeographical and evolutionary modelling to test associations between land ownership and environmental, subsistence and cultural contact predictors. Location Africa. Taxon...
The hidden cost of road maintenance due to the increased weight of battery and hydrogen trucks and buses—a perspectiveNARA Subscribed
Decarbonisation of transport emissions is essential to meet climate targets. For road transport, currently available technologies are battery electric vehicles and hydrogen fuel cell electric vehicles. Battery vehicles are more established than hydrogen; both could deliver the emissions reduction required. However, battery vehicles are considerably heavier than equivalent hydrogen vehicles, which are in turn slightly heavier t...
Prolonging survival in good health is a fundamental societal goal. However, the leading determinants of disability-free survival in healthy older people have not been well established. Data from ASPREE, a bi-national placebo-controlled trial of aspirin with 4.7 years median follow-up, was analysed. At enrolment, participants were healthy and without prior cardiovascular events, dementia or persistent physical disability. Disab...
Background Humans display an age-related decline in cerebral blood flow and increase in blood pressure (BP), but changes in the underlying control mechanisms across the lifespan are less well understood. We aimed to; (1) examine the impact of age, sex, cardiovascular disease (CVD) risk, and cardio-respiratory fitness on dynamic cerebral autoregulation and cardiac baroreflex sensitivity, and (2) explore the relationships betwee...